High-transmittance interface assembly core-shell type all-liquid device, preparation method and mechanical property regulation and control method thereof

A technology with high transmittance and interface, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, drug combinations, etc., can solve the long-term maintenance of unfavorable droplet structure stability, hydrogel package Problems such as poor permeation and exchange performance of the coating layer and poor swelling resistance of the hydrogel can achieve the effect of continuous operation, large-scale production, and simple preparation process

Pending Publication Date: 2021-11-16
香港城市大学深圳研究院
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  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Although the hydrogel-coated droplets solve the problem of droplet coalescence, the osmotic exchange performance of the hydrogel coating is still poor, and its existence increases additional osmotic resistance, making the droplet’s permeability poor. Ideal, it is not conducive to the osmotic exchange between droplets and the surrounding environment; the swelling resistance of ionically cross-linked hydrogels is poor in inorganic salt solutions, which is not conducive to the long-term maintenance of the stability of the droplet structure

Method used

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  • High-transmittance interface assembly core-shell type all-liquid device, preparation method and mechanical property regulation and control method thereof
  • High-transmittance interface assembly core-shell type all-liquid device, preparation method and mechanical property regulation and control method thereof
  • High-transmittance interface assembly core-shell type all-liquid device, preparation method and mechanical property regulation and control method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0047] This embodiment provides a method for preparing an interface-assembled core-shell droplet with high transmittance, which is carried out according to the following specific steps:

[0048] dissolving sodium alginate in water to obtain a sodium alginate aqueous solution with a concentration of 1.5% as a dispersed phase;

[0049] Dissolving ε-polylysine in water to obtain a 1.0% aqueous solution of ε-polylysine as the continuous phase;

[0050] The dispersed phase was added to the continuous phase in the form of droplets at a constant rate through a syringe pump, and the core-shell droplets were obtained through the interfacial assembly of sodium alginate and ε-polylysine, denoted as Alg@ε-PL, the interface The assembly temperature is 25°C, and the time is 10-50s;

[0051] The Alg@ε-PL was taken out and washed with distilled water to obtain core-shell droplets.

[0052] figure 2 This is the optical image of the core-shell droplet and the fluorescent staining of the cla...

Embodiment 2

[0056] This example provides a method for preparing an interface-assembled core-shell droplet with high transmittance, which is carried out according to the following specific steps:

[0057] dissolving sodium alginate in water to obtain a 2% sodium alginate aqueous solution as a dispersed phase;

[0058] Dissolving ε-polylysine in water to obtain a 1.0% aqueous solution of ε-polylysine as the continuous phase;

[0059] The dispersed phase was added to the continuous phase in the form of droplets at a constant rate through a syringe pump, and the core-shell droplets were obtained through the interfacial assembly of sodium alginate and ε-polylysine, denoted as Alg@ε-PL, the interface The assembly temperature is 25°C, and the time is 20s, 30s and 40s respectively;

[0060] The Alg@ε-PL was taken out and washed with distilled water to obtain core-shell droplets.

[0061] Figure 4 It is a schematic diagram of visible light transmission of core-shell droplets prepared in Exampl...

Embodiment 3

[0063] This example provides a method for preparing an interface-assembled core-shell droplet with high transmittance, which is carried out according to the following specific steps:

[0064] Sodium alginate is dissolved in water to obtain sodium alginate aqueous solutions with concentrations of 2% and 3%, respectively, as the dispersed phase;

[0065] Dissolving ε-polylysine in water to obtain a 1.0% aqueous solution of ε-polylysine as the continuous phase;

[0066] The dispersed phase was added to the continuous phase in the form of droplets at a constant rate through a syringe pump, and the core-shell droplets were obtained through the interfacial assembly of sodium alginate and ε-polylysine, denoted as Alg@ε-PL, The temperature of the interface assembly is 25°C, and the time is 10s-50s;

[0067] The Alg@ε-PL was taken out and washed with distilled water to obtain core-shell droplets.

[0068] Figure 5 The change diagram of the visible light transmittance with time at d...

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Abstract

The invention provides a high-transmittance interface assembly core-shell type all-liquid device, a preparation method and a mechanical property regulation and control method of the high-transmittance interface assembly core-shell type all-liquid device. The preparation method comprises the following steps: taking a sodium alginate solution as a dispersion phase and an epsilon-polylysine solution as a continuous phase; adding the dispersion phase into the continuous phase, and obtaining the core-shell type all-liquid device through interface assembly of sodium alginate and epsilon-polylysine. The regulation and control method comprises the following steps: soaking a core-shell type all-liquid device in an aqueous solution containing calcium ions, and curing the core-shell type all-liquid device through Ca<2+>; and washing the cured core-shell type all-liquid device, soaking the cured core-shell type all-liquid device in an aqueous solution of a substance which can compete with Ca<2+> for coordination, and adjusting the concentration of the aqueous solution to obtain the high-transmittance interface assembly core-shell type all-liquid devices with different mechanical properties. According to the preparation method provided by the invention, an all-liquid device with a high-permeability core-shell structure is prepared by utilizing an interface assembly technology.

Description

technical field [0001] The invention relates to an interface-assembled core-shell type all-liquid device with high transmittance, a preparation method and a mechanical property regulation method thereof, and belongs to the technical field of micro-droplet preparation. Background technique [0002] All-liquid devices such as droplets have small volumes independent of each other, and can be easily mass-produced, so they are of great significance to biotechnology at the micro-nano scale, such as micro-biochemical reactions and high-throughput screening. [0003] Conventional droplet preparation can be achieved by emulsifying incompatible two-phase aqueous phases. For example, the binary two-phase aqueous solution of emulsified polyethylene glycol (PEG) and dextran (DEX) can be used to obtain dispersed droplets to achieve three-dimensional Cell culture under environmental conditions (such as methods disclosed in US20140120573A1, WO2016044681A1). However, this method only uses t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00C08J3/24C08J3/00A61K47/34A61K47/36A61K31/5377A61P35/00C08L87/00
CPCC08G83/008C08J3/24C08J3/00A61K47/34A61K47/36A61K31/5377A61P35/00C08J2387/00
Inventor 姚希黄鑫
Owner 香港城市大学深圳研究院
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