Application of GGPP combined and allosteric activated human FBP1 in preparation of medicine for resisting hepatocellular carcinoma
A hepatocellular carcinoma, human-derived technology, applied in the biological field to achieve the effect of inhibiting migration
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[0046] The GGPP probe with Biotin tag was used to enrich the GGPP-binding protein in primary mouse liver parenchymal cells by using the biotin-streptavidin affinity purification system and detected by mass spectrometry, and screened out multiple glycolipids Metabolism-related GGPP potential target proteins, such as fructose-1,6-bisphosphatase 1 (Fructose-1,6-bisphosphatase, FBP1) in the gluconeogenesis pathway, liver pyruvate kinase (Liver pyruvate kinase) in the glycolysis pathway , LPK) and carnitine palmitoyl transferase 1 (Carnitine palmitoyl transferase 1, CPT1) involved in lipid oxidation, etc. Among them, FBP1 due to the significance of binding to GGPP (such as Figure 5-8 shown), its important role in the regulation of glucose and lipid metabolism, and its correlation with various cancers have attracted attention.
[0047] 1. Establish a technical route for the enrichment and identification of metabolic small molecule GGPP direct binding proteins
[0048] 1.1 Design ...
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