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Acellular matrix fiber sponge, and preparation method and application thereof

An acellular matrix and fiber technology, applied in the field of acellular matrix fiber sponge and its preparation, can solve the problems of secondary tearing, easy growth into the sponge, etc., and achieve the effect of reducing secondary damage

Inactive Publication Date: 2021-11-30
江苏优创生物医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Negative pressure drainage system has been widely used in wound coverage treatment and negative pressure sealing drainage operation treatment caused by burns, trauma, surgery, infection and other reasons. However, in the process of wound recovery, tissues tend to grow into it. Contact with the sponge in the vacuum drainage system, resulting in secondary tearing during dressing changes or removal

Method used

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  • Acellular matrix fiber sponge, and preparation method and application thereof
  • Acellular matrix fiber sponge, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Such as figure 1 As shown, the present embodiment provides a kind of acellular matrix fiber sponge, and its preparation steps include:

[0030] S1. Take the wet acellular matrix and cut it into a size less than 1cm 2 After the fragments, carry out high-speed mashing in a short time (no more than 1min);

[0031] S2. Take 0.5% (wet weight) of the acellular matrix, 0.01% glacial acetic acid and the rest of purified water by weight percentage, mix and cool down to 2°C;

[0032] S3. Perform homogenization at a frequency of 25 Hz, and then homogenize the collected feed liquid 3 times, filter out coarse particles, and use a 6% NaOH solution to adjust the pH of the filtered slurry to 7.0 , to obtain decellularized matrix fibers after centrifugation;

[0033] S4. Take the acellular matrix fiber, make an aqueous dispersion with a mass fraction of 0.5%, and adjust the pH value to 4; cover the acellular matrix fiber with a polyurethane sponge layer or a polyvinyl alcohol sponge ...

Embodiment 2

[0036] Such as figure 2 As shown, the present embodiment provides another acellular matrix fiber sponge, the steps of its preparation comprising:

[0037] S1. Take the wet acellular matrix and cut it into a size less than 1cm 2 After the fragments, carry out high-speed mashing in a short time (no more than 1min);

[0038] S2. Take 3.0% (wet weight) of the acellular matrix, 0.1% glacial acetic acid and the rest of purified water by weight percentage, mix and cool down to 8°C;

[0039] S3. Perform homogenization at a frequency of 29 Hz, and then homogenize the collected feed liquid 3 times, filter out coarse particles, and use an 8% NaOH solution to adjust the pH of the filtered slurry to 7.5 , to obtain decellularized matrix fibers after centrifugation;

[0040] S4. Take the acellular matrix fiber, make an aqueous dispersion with a mass fraction of 10%, adjust the pH value to 8, and then add silver sulfadiazine dispersion according to the solid content until the silver elem...

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Abstract

The invention relates to a preparation method of an acellular matrix fiber sponge. The preparation method comprises the following steps of: taking a wet acellular matrix, cutting the acellular matrix into fragments, and mashing the fragments at a high speed in a short time; taking the acellular matrix, glacial acetic acid and purified water, mixing and cooling; homogenizing at certain frequency, homogenizing the collected feed liquid for multiple times, filtering out coarse particles, adjusting the pH value of filtered slurry by using a NaOH solution, and centrifuging to obtain acellular matrix fibers; taking the acellular matrix fibers, preparing the acellular matrix fibers into aqueous dispersion liquid with the mass fraction of 0.5%-10%, and adjusting the pH value to 4-8; and covering the acellular matrix fiber with a polyurethane sponge layer or a polyvinyl alcohol sponge layer, then, performing vacuum freeze drying, cutting, packaging and sterilizing to obtain the acellular matrix fiber sponge. The acellular matrix fiber sponge disclosed by the invention is in direct contact with a wound surface, so that tissues are prevented from growing into the acellular matrix fiber sponge, and secondary injury caused by dressing change or taking down is reduced.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to an acellular matrix fiber sponge and its preparation method and application. Background technique [0002] Negative pressure drainage system has been widely used in wound coverage treatment and negative pressure sealing drainage operation treatment caused by burns, trauma, surgery, infection and other reasons. However, in the process of wound recovery, tissues tend to grow into it. Contact with the sponge in the negative pressure drainage system, resulting in secondary tearing during dressing changes or removal. [0003] Therefore, there is an urgent need for an acellular matrix fiber sponge and its preparation method and application. Contents of the invention [0004] The object of the present invention is to provide a decellularized matrix fiber sponge and its preparation method and application to address the deficiencies in the prior art. [0005] For realizin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/40A61L15/42A61L15/26A61L15/24A61F13/02A61F13/00
CPCA61L15/40A61L15/425A61F13/0206A61L15/26A61L15/24A61F13/05
Inventor 潘华倩潘银根吴锋陈件忠
Owner 江苏优创生物医学科技有限公司
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