Acellular matrix fiber sponge, and preparation method and application thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
An acellular matrix and fiber technology, applied in the field of acellular matrix fiber sponge and its preparation, can solve the problems of secondary tearing, easy growth into the sponge, etc., and achieve the effect of reducing secondary damage
Inactive Publication Date: 2021-11-30
江苏优创生物医学科技有限公司
View PDF3 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0002] Negative pressure drainage system has been widely used in wound coverage treatment and negative pressure sealing drainage operation treatment caused by burns, trauma, surgery, infection and other reasons. However, in the process of wound recovery, tissues tend to grow into it. Contact with the sponge in the vacuum drainage system, resulting in secondary tearing during dressing changes or removal
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0029] Such as figure 1 As shown, the present embodiment provides a kind of acellular matrix fiber sponge, and its preparation steps include:
[0030] S1. Take the wet acellular matrix and cut it into a size less than 1cm 2 After the fragments, carry out high-speed mashing in a short time (no more than 1min);
[0031] S2. Take 0.5% (wet weight) of the acellular matrix, 0.01% glacial acetic acid and the rest of purified water by weight percentage, mix and cool down to 2°C;
[0032] S3. Perform homogenization at a frequency of 25 Hz, and then homogenize the collected feed liquid 3 times, filter out coarse particles, and use a 6% NaOH solution to adjust the pH of the filtered slurry to 7.0 , to obtain decellularized matrix fibers after centrifugation;
[0033] S4. Take the acellular matrix fiber, make an aqueous dispersion with a mass fraction of 0.5%, and adjust the pH value to 4; cover the acellular matrix fiber with a polyurethane sponge layer or a polyvinyl alcohol sponge ...
Embodiment 2
[0036] Such as figure 2 As shown, the present embodiment provides another acellular matrix fiber sponge, the steps of its preparation comprising:
[0037] S1. Take the wet acellular matrix and cut it into a size less than 1cm 2 After the fragments, carry out high-speed mashing in a short time (no more than 1min);
[0038] S2. Take 3.0% (wet weight) of the acellular matrix, 0.1% glacial acetic acid and the rest of purified water by weight percentage, mix and cool down to 8°C;
[0039] S3. Perform homogenization at a frequency of 29 Hz, and then homogenize the collected feed liquid 3 times, filter out coarse particles, and use an 8% NaOH solution to adjust the pH of the filtered slurry to 7.5 , to obtain decellularized matrix fibers after centrifugation;
[0040] S4. Take the acellular matrix fiber, make an aqueous dispersion with a mass fraction of 10%, adjust the pH value to 8, and then add silver sulfadiazine dispersion according to the solid content until the silver elem...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
thickness
aaaaa
aaaaa
quality score
aaaaa
aaaaa
Login to view more
Abstract
The invention relates to a preparation method of an acellular matrix fiber sponge. The preparation method comprises the following steps of: taking a wet acellular matrix, cutting the acellular matrix into fragments, and mashing the fragments at a high speed in a short time; taking the acellular matrix, glacial acetic acid and purified water, mixing and cooling; homogenizing at certain frequency, homogenizing the collected feed liquid for multiple times, filtering out coarse particles, adjusting the pH value of filtered slurry by using a NaOH solution, and centrifuging to obtain acellular matrix fibers; taking the acellular matrix fibers, preparing the acellular matrix fibers into aqueous dispersion liquid with the mass fraction of 0.5%-10%, and adjusting the pH value to 4-8; and covering the acellular matrix fiber with a polyurethane sponge layer or a polyvinyl alcohol sponge layer, then, performing vacuum freeze drying, cutting, packaging and sterilizing to obtain the acellular matrix fiber sponge. The acellular matrix fiber sponge disclosed by the invention is in direct contact with a wound surface, so that tissues are prevented from growing into the acellular matrix fiber sponge, and secondary injury caused by dressing change or taking down is reduced.
Description
technical field [0001] The invention relates to the technical field of biological materials, in particular to an acellular matrix fiber sponge and its preparation method and application. Background technique [0002] Negative pressure drainage system has been widely used in wound coverage treatment and negative pressure sealing drainage operation treatment caused by burns, trauma, surgery, infection and other reasons. However, in the process of wound recovery, tissues tend to grow into it. Contact with the sponge in the negative pressure drainage system, resulting in secondary tearing during dressing changes or removal. [0003] Therefore, there is an urgent need for an acellular matrix fiber sponge and its preparation method and application. Contents of the invention [0004] The object of the present invention is to provide a decellularized matrix fiber sponge and its preparation method and application to address the deficiencies in the prior art. [0005] For realizin...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more