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Method for identifying chemical components in Xuebijing injection

A technology for chemical components and injections, applied in the field of traditional Chinese medicine component identification, can solve problems such as the detection and identification of chemical components of Nanxuebijing injection, and achieve the effects of high sensitivity, strong specificity and fast analysis speed.

Active Publication Date: 2021-12-14
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitations of existing analytical techniques, it is difficult to conduct a comprehensive and accurate detection and identification of the chemical composition of Xuebijing Injection. and valid identification

Method used

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  • Method for identifying chemical components in Xuebijing injection
  • Method for identifying chemical components in Xuebijing injection
  • Method for identifying chemical components in Xuebijing injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Example 1 Test sample identification

[0095] (1) Take the Xuebijing injection to be tested and filter it through a 0.22 μm microporous membrane to obtain the sample solution to be tested;

[0096] (2) Through ultra-high performance liquid chromatography-ion mobility-quadrupole time-of-flight mass spectrometry, the retention time, parent ion mass-to-charge ratio, secondary fragment ion mass-to-charge ratio and parent ion Collision cross section value;

[0097] Among them, the chromatographic conditions of ultra-high performance liquid chromatography include:

[0098] Chromatographic column: Zorbax Eclipse Plus C18 chromatographic column (2.1×100mm, 1.8μm);

[0099] Mobile phase: Phase A is formic acid aqueous solution with a volume fraction of 0.1%, phase B is acetonitrile; column temperature: 40°C; flow rate: 0.3mL / min; injection volume V 1 : 3μL; gradient elution: 0-3 minutes, 1-5% phase B; 3-4 minutes, 5-15% phase B; 4-7 minutes, 15-15% phase B; 7-12 minutes, 15- ...

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Abstract

The invention provides a method for identifying the chemical components in the Xuebijing injection. The ultra-high performance liquid chromatography-ion mobility-quadrupole time-of-flight mass spectrometry is combined, and the identification of multiple types of chemical components in the Xuebijing injection can be realized by reasonably selecting chromatographic conditions and mass spectrometry conditions; and the method has the advantages of simplicity, convenience, high sensitivity, high analysis speed, strong specificity and the like, and provides a basis for further researching the pharmacodynamic material basis of the Xuebijing injection.

Description

technical field [0001] The present application relates to the technical field of identification of traditional Chinese medicine components, in particular to a method for identification of chemical components in Xuebijing injection. Background technique [0002] Xuebijing Injection is composed of safflower, red peony root, Chuanxiong, red sage root, and angelica. Its function is to remove stasis and detoxify. It is used for warm-heat diseases. . In order to clarify the chemical substance basis of Xuebijing injection and find its active ingredients, it is necessary to detect and identify the chemical composition of Xuebijing injection. However, due to the limitations of existing analytical techniques, it is difficult to conduct a comprehensive and accurate detection and identification of the chemical composition of Xuebijing Injection. And valid identification. Contents of the invention [0003] The purpose of this application is to provide a method for identifying the ch...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/72G01N30/86
CPCG01N30/02G01N30/06G01N30/72G01N30/8679G01N2030/065Y02A50/30
Inventor 杨文志李雪胡莹钱悦新胡万弟
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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