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Biomarker for analyzing recurrence risk of acute ischemic stroke and application thereof

A technology of ischemic stroke and biomarkers, applied in the field of biomarkers, can solve the problems that there are no biomarkers for prognosis and recurrence warning of acute ischemic stroke, and cannot meet clinical needs, so as to improve clinical services Effect

Active Publication Date: 2021-12-14
BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no prognostic and recurrence early warning biomarkers for acute ischemic stroke in the international and domestic markets, which cannot meet clinical needs

Method used

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  • Biomarker for analyzing recurrence risk of acute ischemic stroke and application thereof
  • Biomarker for analyzing recurrence risk of acute ischemic stroke and application thereof
  • Biomarker for analyzing recurrence risk of acute ischemic stroke and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 1. Clinical data collection of patients with acute ischemic stroke and healthy control group: stroke type CCS type, NIHSS score, biochemical indicators, imaging, etc.

[0060] 2. Collection and storage of samples from patients with acute ischemic stroke and healthy controls.

[0061] Peripheral blood was collected in purple tubes containing anticoagulant EDTA or heparin, and centrifuged within 30 minutes after sample collection, at 3000 rpm for 10 minutes, at 2-8°C. The upper plasma layer was collected and stored in batches at -80°C. Avoid repeated freezing and thawing of samples. Note: Samples should be centrifuged sufficiently to avoid hemolysis or the presence of particles.

[0062] 3. Analyze genes and proteomics, screen out differentially expressed proteins, and form a Biomarkerpanel for recurrence and prognosis assessment.

[0063] 3.1 This project uses the next-generation label-free quantitative proteomics technology to complete the analysis. In the data-indep...

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PUM

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Abstract

The invention discloses a biomarker for analyzing the recurrence risk of acute ischemic stroke and application of the biomarker. According to the present invention, by developing a reagent or a product capable of detecting the expression level of the target protein, the early recurrence of the acute ischemic stroke can be effectively analyzed, and the target protein is one or more of BID, CAH3, CO1A2, HORN, ITAM, KAD1, MYL9, PARK7, PRDX1, RSU1, TAGLN2 and TRML1. The invention further develops a specific biomarker and a combination thereof aiming at acute ischemic cerebral apoplexy of CCS1, CCS3 and CCS5 subtypes, so that recurrence of acute ischemic cerebral apoplexy of different subtypes can be effectively analyzed in a more targeted manner.

Description

technical field [0001] The invention relates to the technical field of biomarkers, in particular to biomarkers used for risk analysis of recurrence of acute ischemic stroke. Background technique [0002] Cerebrovascular disease (Cerebralvascular disease, CVD) includes transient ischemic attack (Transientischemic attack, TIA) and stroke (Stroke). Among them, stroke has surpassed cardiovascular diseases and malignant tumors to become the leading cause of death and disability among Chinese residents, causing huge economic and social burdens, including acute ischemic stroke (AIS) and hemorrhagic stroke (Intracerebral stroke). hemorrhage, ICH). AIS, also known as acute cerebral infarction, is a group of clinical syndromes in which the blood supply of brain tissue is impaired due to various reasons, and the resulting ischemia-hypoxic necrosis leads to neurological dysfunction. Acute ischemic stroke is the most common type of stroke, accounting for about 60%-80% of all strokes. ...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/2871G01N2800/60G01N2800/54C12Q1/6883C12Q2600/118C12Q2600/158C12Q2600/178G01N2800/52
Inventor 王拥军施福东孟霞金薇娜张程祎贺文艳魏常娟
Owner BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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