Clock oscillator of biochemical reaction computer

A technology of clock oscillator and biochemical reaction, which is applied in the measurement/inspection of microorganisms, biochemical equipment and methods, generation/distribution of signals, etc., can solve the problems of slow speed and long clock cycle, and achieve fast speed and short clock cycle , the effect of flexible use

Pending Publication Date: 2021-12-17
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

Currently existing clock oscillators based on DNA cascade displacement reactions and DNA transcription and translation systems, due to the slow speed of the reactions involving DNA and RNA they rely on, their clock cycles are relatively long and often take several hours. This is difficult to meet the needs of building high-performance biochemical computers, and it is necessary to find more efficient biochemical reactions and build new biochemical reaction clock oscillators

Method used

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  • Clock oscillator of biochemical reaction computer
  • Clock oscillator of biochemical reaction computer
  • Clock oscillator of biochemical reaction computer

Examples

Experimental program
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Effect test

Embodiment

[0019] like figure 1 As shown, the present embodiment provides a clock oscillator of a biochemical reaction computer, the clock oscillator includes clock signal enzyme A and anti-clock signal enzyme B, and involves the inactivation of clock signal enzyme A and anti-clock signal enzyme B Products: inactivated clock semaphore A' and inactivated anti-clock semaphore B'. The clock signaling enzyme A and the inactive clock signaling enzyme A' can be transformed into each other. The clock signaling enzyme B and the inactive anti-clock signaling enzyme B' can be transformed into each other. Transformations between these substances involve the following reactions:

[0020]

[0021] A'→A

[0022]

[0023] B→B'

[0024] As stated in the above formula, B can inhibit the activity of A by catalyzing the conversion of A to A'; without the participation of B, A' can also spontaneously convert to A to regain activity; A can promote the activity of A by catalyzing the conversion of ...

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Abstract

The invention discloses a clock oscillator of a biochemical reaction computer based on enzymatic reaction, and the clock oscillator takes the concentration or activity of substances or enzymes as signals, and realizes self-feedback regulation and control of chemical signals through the mutual catalytic action of various enzymes and substances, so as to output periodically changing chemical signals. Compared with a traditional electronic oscillator, the clock oscillator provided by the invention has the advantages that the output signal of the clock oscillator is a chemical signal, so that the clock oscillator can be directly used in a biochemical reaction computer without conversion between an electric signal and the chemical signal. Compared with the existing clock oscillator based on DNA, the clock oscillator provided by the invention has the advantages that the enzymatic reaction has higher reaction speed than the DNA replacement reaction and the DNA transcription translation process, so that the clock oscillator provided by the invention has higher frequency and can meet higher-performance numerical operation and logic calculation based on biochemical reaction.

Description

technical field [0001] The invention relates to the technical field of biochemical computers, in particular to a clock oscillator for a biochemical reaction computer based on enzymatic reactions. Background technique [0002] Imitating the principles of biological regulation in nature, building a biochemical computer with high performance and low power consumption is a subject with great potential at present. In traditional electronic computers and biochemical computers, the clock oscillator on which synchronous sequential logic depends is important. component. Currently existing clock oscillators based on DNA cascade displacement reactions and DNA transcription and translation systems, due to the slow speed of the reactions involving DNA and RNA they rely on, their clock cycles are relatively long and often take several hours. This is difficult to meet the needs of building high-performance biochemical computers, and it is necessary to find more efficient biochemical react...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F1/08C12Q1/00
CPCG06F1/08C12Q1/00
Inventor 黄翰马诚志肖性龙何同立
Owner SOUTH CHINA UNIV OF TECH
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