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Non-hla markers of transplant rejection

A technology of composition and binding agent, which is applied in biological testing, biological material analysis, medical preparations containing active ingredients, etc., and can solve problems such as restricting the use of immunosuppression

Pending Publication Date: 2021-12-21
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In all cases, although aggressive immunosuppression is indicated to reverse or correct the immune response, the associated risk of promoting opportunistic infections limits the use of immunosuppression

Method used

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  • Non-hla markers of transplant rejection
  • Non-hla markers of transplant rejection
  • Non-hla markers of transplant rejection

Examples

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Embodiment approach 1

[0125] Embodiment 1: A composition comprising a collection of solid substrates coated with one or more populations of homogeneous binding agents, wherein each population of homogeneous binding agents specifically binds an antibody directed against a single antigen, wherein Said single antigen is selected from the group consisting of: dexamethasone-induced transcript (DEXI), C-X-C motif chemokine ligand 11 (CXCL11), cytokeratin 18 (KRT18), cytokeratin 8 (KRT8), Tubulins (including tubulin α1b (also known as TUBα1b or TUBA1B)), spirotoxin receptor 1 (LPHN1), colony-stimulating factor 2 (CSF2), signal transducer and activator of transcription 6 (STAT6), soluble Galectin 3-binding protein (LGALS3), SHC adapter protein 3 (SHC3), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), glutathione S-transferase θ-1 (GSTT1), phospholipase A2 receptor 1 (PLA2R1), interleukin 8 (IL-8), soluble galectin 8-binding protein (LGALS8), small nuclear ribonucleoprotein polypeptide N (SNPRN), myosin, ...

Embodiment approach 2

[0126] Embodiment 2: The composition of embodiment 1, wherein said collection of solid substrates further comprises one or more additional populations of homogeneous binding agents, wherein each additional population of homogeneous binding agents specifically binds to a single Antibodies to additional antigens, the single additional antigen selected from the group consisting of: α-enolase (ENO1), agrin (AGRN), endothelial mucin (EMCN), Sjögren syndrome antigen B (SSB), actin protein, fms-related tyrosine kinase 3 ligand (FLT3LG), protein kinase Cn (PRKCH), and interleukin 21 (IL-21).

Embodiment approach 3

[0127] Embodiment 3: The composition of Embodiment 1 or 2, wherein the solid substrate is porous or non-porous.

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Abstract

The present invention generally relates to transplantation rejection. In particular, the present invention provides compositions, kits, assays, and methods of determining if a subject has allograft rejection, or an increased risk of developing rejection after transplantation, and methods of treatment thereof.

Description

[0001] This application claims the benefit of U.S. Provisional Patent Application No. 62 / 844,027, filed May 6, 2019, which is hereby incorporated by reference in its entirety. [0002] Acknowledgments for government support [0003] This invention was made with Government support under Contract Nos. AI042819, AI135201, and DK104687 awarded by the National Institutes of Health. The government has certain rights in this invention. technical field [0004] The present invention relates generally to organ transplant rejection. In particular, the invention provides compositions, kits, assays and methods for determining whether a subject has allograft rejection or an increased risk of developing rejection following transplantation, and methods of treatment. Additionally, the invention provides biomarkers associated with transplant rejection, such as non-HLA antibodies. Background technique [0005] Transplantation of organs from donors to host recipients is a feature of certain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/00C07K5/00C40B30/04C40B30/10G01N33/53
CPCG01N33/6893G01N2800/245
Inventor E·F·里德M·希基C·L·巴特勒D·W·杰特森
Owner RGT UNIV OF CALIFORNIA
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