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Application of seaweed extract GV971 in preparation of medicine for treating polycystic ovarian syndrome

A technology of seaweed extract and GV971, applied in the field of biomedicine, can solve problems such as unreported, and achieve the effects of increasing the number of pregnant embryos, the number of corpora lutea, and improving ovulation abnormalities

Active Publication Date: 2021-12-24
THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there is no report about the application of the seaweed extract GV971 of the present invention in the preparation of medicines for the treatment of polycystic ovary syndrome

Method used

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  • Application of seaweed extract GV971 in preparation of medicine for treating polycystic ovarian syndrome
  • Application of seaweed extract GV971 in preparation of medicine for treating polycystic ovarian syndrome
  • Application of seaweed extract GV971 in preparation of medicine for treating polycystic ovarian syndrome

Examples

Experimental program
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Effect test

Embodiment 1

[0058] Example 1 Animal Experiment in Treating Polycystic Ovary Syndrome by Seaweed Extract

[0059] 1 material and method

[0060] 1.1 experimental mice

[0061] 3 week old female C57BL / 6 mice were purchased from Shanghai Jiejie Experimental Animal Co., Ltd., SPF level. The male mouse used in fertility experiments is a total of 10 weeks old and normal fertility. It is purchased from Shanghai Jiejie Experimental Animal Co., Ltd., SPF.

[0062] 1.2 mice feeding

[0063] All mice raised in Shanghai's internal secretion focus laboratory animal room, 3-5 / cage, and the feeding temperature was maintained at 21-25 ° C, and the photographic time of 12L: 12D was free to eat water. Animals used in the experiment were approved by the Animal Ethics Committee of the Fudan Obstetrics and Gynecology Hospital.

[0064] 1.3PCOS mouse model establishment

[0065] The zrazole model, 21 days of size C57BL / 6 female mouse neck buried diameter of 3 mm to bezazole sustain sheet (50 ng / d) 21 days,...

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Abstract

The invention relates to application of a seaweed extract GV971 in preparation of a medicine for treating the polycystic ovarian syndrome. The seaweed extract GV971 is an acidic oligosaccharide sugar chain (AOSC) compound. Experiments show that the GV971 can treat the polycystic ovarian syndrome, regulate the hormone level, eliminate a reproductive abnormality phenotype or regulate the intestinal flora. The GV971 can alleviate metabolism and reproductive abnormality phenotypes of letrozole mice, and an improvement effect is achieved by adjusting disorder of intestinal flora and further improving the activation state of local ovarian inflammation. The seaweed extract GV971 is natural in source, is safe, is reliable, is free of obvious toxic and side effects and is suitable for clinical application and popularization.

Description

Technical field [0001] The present invention relates to the field of biopharmaceutical technology, and in particular, the application of algae extract GV971 in the preparation of the treatment of polycystic ovary syndrome. Background technique [0002] Polycystic ovary syndrome (PCOS) is a complicated endocrine and metabolic abnormal disease, with a chronic non-ovulation (dysfunction or loss) and high-tech hormones in women. Features, main clinical manifestations are irregular menstrual cycles, infertility, multi-hairy and / or acne, is the most common female endocrine disease. [0003] Algae extract GV971 is an acid oligosaccharide sugar chain (AOSC) compound. AOSC is derived from the Nchlonia Kurome Okam, which can induce apoptosis of mice Haijia nervania in mice. The synthesis of the series AOSC derivatives found that GV971 can bind directly to Aβ to prevent apoptosis of SH-SY5Y cells induced by Aβ. GV971 oral absorption is good and can quickly pass the blood brain barrier; it...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K31/702A61K31/7016A61K31/7012A61K36/02A61P15/00A61P5/00A61P1/00
CPCA61K31/715A61K31/702A61K31/7016A61K31/7012A61K36/02A61P15/00A61P5/00A61P1/00Y02A50/30
Inventor 刘海鸥徐丛剑张菲菲柳妍李智蔡青青王阳
Owner THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV
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