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Hormonal regulation of hormone release involves a hormone binding to its receptor on an endocrine cell to regulate hormonal secretion. A hormone that regulates hormone secretion is called a tropic hormone. Tropic hormones may also stimulate proliferation of endocrine cells.
Glucose control using digital twin metabolic models
PCT designated stageWO2025165924A9Medical simulationPhysical therapies and activitiesLow glucosePhysiology
A diabetes management system optimizes glucoregulatory hormone delivery using a connected glucoregulatory hormone delivery system and a computing device with a processor and non-transitory memory. The system receives glucose management data (glucose, insulin delivery, heart rate, or carbohydrate consumption data) from sensors. A digital twin metabolic model is selected and initialized based on the received data. The system simulates diabetes treatment interventions to predict glucose dynamics and determines an optimized glucoregulatory hormone parameter (e.g., insulin dose or increment that minimizes hyperglycemia and hypoglycemia risk). The determined glucoregulatory hormone parameter is transmitted to the connected glucoregulatory hormone delivery system, which may include an automated insulin delivery (AID) system or a connected insulin pen system, for implementation. By integrating real-time physiological data with predictive metabolic modeling, the system enhances glucoregulatory hormone therapy, providing personalized adjustments to improve glucose control.
Owner:OREGON HEALTH & SCI UNIV