Magnetic andrographolide imprinted polymer as well as preparation method and application thereof

A technology of andrographolide and imprinted polymer is applied in the field of analytical chemistry to achieve the effects of fast adsorption, improved adsorption and separation efficiency, and easy operation.

Pending Publication Date: 2021-12-31
CHENGDU TONGDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is no report in the prior art that magnetic nanoparticles are involved in the preparation of andrographolide-imprinted polymers. Therefore, it is very meaningful to prepare magnetic andrographolide-imprinted polymers

Method used

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  • Magnetic andrographolide imprinted polymer as well as preparation method and application thereof
  • Magnetic andrographolide imprinted polymer as well as preparation method and application thereof
  • Magnetic andrographolide imprinted polymer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A preparation method of magnetic andrographolide imprinted polymers (MMIPs), comprising the following steps:

[0045] (1) After mixing 32g of emulsifier OP-10, 45ml of n-butanol and 100ml of cyclohexane evenly, add it to the 2 In the three-neck flask of the catheter;

[0046] (2) 3.5mmol FeCl 3 ·6H 2 O and 2.1 mmol FeSO 4 ·7H 2 O was dissolved in 50ml of deionized water, added to the three-necked flask in step (1), and then added dropwise with 6ml of concentrated ammonia water until the pH was 11, and then reacted at 25°C for 1h. This process produced Fe 3 o 4 particles;

[0047] (3) After the reaction in step (2), add 2ml KH570 to the reaction system and react at 50°C for 5h;

[0048] (4) Dissolve 0.6mmol andrographolide and 0.6mmol monomer AM in 50ml 60% ethanol solution, stir at room temperature for 5h, add to the system modified by KH570 in step (3), stir for 10min, then add 18mmol Cross-linking agent MBA and 0.086mmol azobisisobutyronitrile (AIBN), reacted ...

Embodiment 2

[0051] The difference from Example 1 is that the monomer AM in Example 1 is replaced by AA, and the rest are consistent with Example 1.

Embodiment 3

[0053] The difference from Example 1 is that the monomer AM in Example 1 is replaced by MAA, and the rest are consistent with Example 1.

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Abstract

The invention discloses a magnetic andrographolide imprinted polymer and a preparation method and application thereof. The preparation method comprises the steps of: adding andrographolide and a monomer into an organic solvent for pre-assembly, then adding the pre-assembly body into a reversed-phase micro-emulsion system containing modified Fe3O4 magnetic nanoparticles, finally adding a cross-linking agent and an initiator, carrying out polymerization reaction at 30-60 DEG C for 25-28 hours, and then removing andrographolide to obtain the magnetic andrographolide imprinted polymer. The magnetic andrographolide imprinted polymer prepared by the method has the advantage that the andrographis paniculata adsorption speed is high, and adsorption equilibrium can be achieved in a short time. The polymer prepared by the method has good magnetism. When the polymer is used for extracting and separating andrographolide, the operation is simpler and more convenient. Selective separation is realized, and a higher recovery rate is obtained.

Description

technical field [0001] The invention relates to the technical field of analytical chemistry, in particular to a magnetic andrographolide imprinted polymer and a preparation method and application thereof. Background technique [0002] Andrographolide has a wide range of clinical indications, and has various pharmacological activities such as anti-inflammatory, anti-tumor, anti-viral, anti-HIV and hepatoprotective. At present, the clinical research on andrographolide for different diseases and different drug dosage forms is gradually increasing, so there are also many researches on its preparation. It has been reported that column chromatography or macroporous adsorption resin is used to separate and purify andrographolide, which requires a large amount of solvent desorption and separation, and then uses silica gel column for decolorization and acetone recrystallization; it is also reported that by integrating solvent removal-solvent extraction separation-column chromatograph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F220/56C08F222/38C08F220/06C08F222/20C08F222/14B01J20/26
CPCC08F292/00C08F2/32C08J9/26B01J20/268C08J2201/0422C08J2351/10C08F220/56C08F222/385C08F220/06C08F222/102C08F222/104
Inventor 蒋达博史凌洋范伟川李永东付春梅张安玲陈熙英张利蓉梁星吴照军赵余武银娜
Owner CHENGDU TONGDE PHARMA
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