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Cornu cervi pantotrichum polypeptide monomer gel preparation for promoting wound healing and preparation method thereof

A deer antler polypeptide and wound healing technology, applied in the field of biomedicine, can solve the problems such as thymosin β10 has not been discovered, and the claims in the field of wound healing have not been found, so as to achieve the benefits of wound healing and moisturizing, enhancement of wound healing speed, and mild conditions. Effect

Pending Publication Date: 2022-01-04
鸳鸯故里(屏南)生态农业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of the patents on appeal address claims in the field of wound healing described in this patent
In addition, after searching the relevant databases, no relevant literature reports and patent information on thymosin β10 in skin wound healing have been found.

Method used

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  • Cornu cervi pantotrichum polypeptide monomer gel preparation for promoting wound healing and preparation method thereof
  • Cornu cervi pantotrichum polypeptide monomer gel preparation for promoting wound healing and preparation method thereof
  • Cornu cervi pantotrichum polypeptide monomer gel preparation for promoting wound healing and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0029] The preparation of embodiment 1 deer antler polypeptide monomer gel preparation

[0030] On the basis of the basic formula, the present invention finally determines the amount of matrix material and humectant in the gel formula by investigating the evaluation indicators such as appearance properties and stability, and finally determines the velvet antler polypeptide monomer gel preparation through process verification experiments. The preparation process:

[0031] 1. Accurately weigh 2g of Carbomer 2020, add 98mL of sterile water (98g), stir, and place at room temperature overnight (more than 12h);

[0032] 2. Weigh 10 g of 1,2-propanediol and add it into the above-mentioned gel matrix (35 g of gel matrix) under stirring conditions to obtain solution A;

[0033] 3. Accurately weigh 1 mg of velvet antler polypeptide and dissolve it in sterile water (appropriate amount, about 10 mL), fully dissolve to obtain solution B.

[0034] 4. Under stirring conditions, mix solutio...

Embodiment 2

[0035] Example 2 Gel preparation wound repair experiment

[0036] By performing wound treatment on the back of the rat, observe the healing situation of the gel preparation of the present invention and the blank control on the back of the rat at 0d, 8d and 16d respectively. The preparation method of the hydrogel of the blank control is exactly the same as that in Example 1 except that the velvet antler polypeptide is not added.

[0037] The results are attached figure 2 As shown, it can be seen that the back healing speed using the hydrogel of the present invention is significantly greater than that of the blank control.

Embodiment 3

[0038] Statistical Analysis of the Number of Skin Appendages, the Number of Proliferating Cells and the Number of Blood Vessels of the Skin After the Gel Preparation Repaired

[0039] The rat skin on day 16 was taken out, fixed in 4.0% paraformaldehyde, and then tissue-embedded and sectioned. The number of skin appendages was analyzed by HE staining, the number of proliferating cells was analyzed by IHC (anti-PCNA antibody), and the number of blood vessels was analyzed by IHC (anti-α-SMA antibody). The results showed that 1) the skin appendages of the gel group were significantly higher than that of the control group; 2) the number of cell proliferation in the gel group was significantly reduced; 3) the number of blood vessels in the gel group was significantly higher than that of the control group ( image 3 );

[0040] The comprehensive results show that the gel can significantly increase the skin appendages and increase the number of blood vessels in the skin, indicating t...

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Abstract

The invention relates to a cornu cervi pantotrichum polypeptide monomer gel preparation for promoting wound healing and a preparation method thereof. The cornu cervi pantotrichum polypeptide monomer gel preparation comprises the following components of a component A: a carbomer gel matrix, 1, 2-propylene glycol, triethanolamine and sterile injection water; and a component B: a functional cornu cervi pantotrichum polypeptide monomer. By designing and compounding the components, the defect that the cornu cervi pantotrichum polypeptide easily loses biological activity in an environment with water and a room temperature environment is overcome, and the gel preparation provided by the invention is proved to be capable of remarkably promoting high-quality healing of wounds.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an antler polypeptide monomer gel preparation for promoting wound healing and a preparation method thereof. Background technique [0002] As the largest and most external organ of the human body, the skin is extremely vulnerable to trauma. So far, poor wound healing and healing barriers are the main clinical problems, and its treatment methods are facing great challenges. With the rapid development of economy and society, the number of various trauma wounded is constantly increasing, and at the same time, chronic refractory wounds caused by diabetes and local radiation therapy are correspondingly increasing. Therefore, there is an urgent need for new methods and means of repairing and treating wounds. [0003] Skin wound healing is the repair of damaged tissue with the aim of restoring physiological and structural function. At present, clinical skin repair mostly uses autol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K38/17A61K47/10A61K47/18A61K47/32A61P17/02
CPCA61K9/06A61K9/0014A61K47/32A61K47/10A61K47/18A61K38/1703A61P17/02
Inventor 肖丽张伟张建广薄纯磊
Owner 鸳鸯故里(屏南)生态农业科技有限公司
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