Rosa laevigata formula granules as well as preparation method and quality detection method thereof

A technology of formula granules and golden cherry seeds, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of low production efficiency, difficulty in powder collection, and low yield. To achieve the effect of improving powder quality, fine powder quality and increasing powder collection rate

Inactive Publication Date: 2022-01-04
BEIJING KANGRENTANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the research process, the applicant found that when preparing the formula granules of Rosa chinensis, the wall sticking phenomenon is serious in the drying stage, it is difficult to collect powder, the yield is low, and the production efficiency is low. Therefore, it is necessary to study a non-sticky, high powder collection rate The preparation process of Fructus Rosae Fructus Formula Granules is of great significance to promote the application of Fructus Rosae Fructus in the pharmaceutical industry

Method used

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  • Rosa laevigata formula granules as well as preparation method and quality detection method thereof
  • Rosa laevigata formula granules as well as preparation method and quality detection method thereof
  • Rosa laevigata formula granules as well as preparation method and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] In this example, the cream yield and catechin transfer rate of Fructus Rosa Rosa Standard Decoction were investigated

[0074] Take 100g of 15 batches of different batches of golden cherry decoction pieces, add 6 times of water to soak for 30 minutes, boil and decoct for 30 minutes, filter while hot with a 150-mesh filter cloth, add 5 times of water to the dregs, boil and decoct for 20 minutes, and use a 150-mesh filter cloth to filter while it is hot. Filter the filter cloth while it is hot, combine the two filtrates, cool the filtrate to room temperature in a water bath, and weigh the total weight of the Dingjinyingzi extract. Weigh one-tenth of the weight of the total extract (standard decoction) and record it as M, place it in an evaporating dish, evaporate to dryness in a water bath, dry at 105°C for 5 hours, cool in a desiccator for 30 minutes, and accurately weigh (M 1 ), placed at 105°C for 1 hour, cooled in a desiccator for 30 minutes, and accurately weighed un...

Embodiment 2

[0088] This example examines the influence of concentration temperature on the content of catechins

[0089] Take 200g of golden cherry decoction pieces (batch number: YP-JYZ-03), add 6 times of water to the decoction pieces for the first decoction, soak for 30 minutes, and boil for 30 minutes; Filter through a mesh filter cloth, and combine the filtrates to obtain the Fructus Rosa Rosa extract, and weigh the total weight. Divide the Fructus Rosa extract into 32 parts, weigh each part in a centrifuge tube, seal it, take 2 parts of it, measure the content of catechins, and place the remaining 30 parts at 65°C and 75°C respectively Under the conditions of three temperatures of 85°C and 85°C, 10 samples were placed at each temperature, and at 3h, 6h, 9h, 15h and 24h respectively, 2 samples at different temperatures were taken to detect the catechin content, and the catechin content The test method is the same as in Example 1, and the average value of 2 samples is taken, and the ...

Embodiment 3

[0094] In this example, the influence of the decoction extraction process on the yield and catechin content was investigated

[0095] Using the orthogonal experiment method, taking the extraction rate and catechin content as indicators, the L 9 (3 4 ) Orthogonal experiment, investigate the amount of water added, decoction times, and decoction time that affect the extraction effect, and determine the optimal extraction process conditions. See Table 3 for the factor levels, Table 4 for the experimental scheme, and Table 5 for the experimental results.

[0096] Table 3 Orthogonal experiment factor level table

[0097] Level Add water / times Extraction times / time Extraction time / minute blank 1 5 1 20 1 2 7 2 40 2 3 9 3 60 3

[0098] Table 4 Orthogonal experiment scheme table

[0099] Test No. Add water / times Extraction times / time Extraction time / minute blank 1 5 1 20 1 2 5 2 40 2 3 5 3 60 3 ...

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Abstract

The invention belongs to the technical field of preparation of formula granules, and particularly relates to rosa laevigata formula granules as well as a preparation method and quality detection method thereof, in particular to the rosa laevigata formula granules as well as the preparation method thereof, a characteristic spectrum of the Rosa laevigata formula granules and a construction method of the characteristic spectrum, and a method for determining the content of catechin in the rosa laevigata formula granules. According to the method provided by the invention, the powder collecting rate of rosa laevigata spray-dried powder can be ensured to be 80% or above, meanwhile, the main active ingredient namely catechin in rosa laevigata decoction pieces can be fully extracted, and the loss is small in the concentrating and drying links, so that the quality of the rosa laevigata formula granules is ensured. The wall sticking phenomenon in the spraying process is greatly improved by controlling the air inlet temperature of spray drying, and the problems that the spray-dried powder is difficult to dry, powder is difficult to collect and wall sticking is serious due to the fact that the rosa laevigata is high in sugar content and low in softening point are solved.

Description

technical field [0001] The invention belongs to the technical field of preparation of formula granules, and in particular relates to a formula granule of Rosa chinensis and a preparation method and a quality detection method thereof, specifically comprising a formula granule of Rosa chinensis and a preparation method thereof, a characteristic map of the formula granule of Rosa chinensis and its Construction method, determination method of catechin content in Jinyingzi formula granules. Background technique [0002] Rosa laevigata Michx. is the dry and mature fruit of Rosa laevigata Michx. It is also known as sugar jar, prickly pear, and pomegranate. It likes warm, humid and sunny environments, and its main production areas are East China, Central China, and South China And the southwestern provinces and autonomous regions, especially Guizhou is the most abundant. "Compendium of Materia Medica" records that Rosa laevigata "is sour in nature, astringent, flat, and non-toxic; ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61K9/16A61K47/36A61P11/00A61P17/02A61P1/00A61P15/00G01N30/02G01N30/06G01N30/54G01N30/74A61K131/00
CPCA61K36/738A61K9/1652A61K9/1682A61P11/00A61P17/02A61P1/00A61P15/00G01N30/02G01N30/06G01N30/54G01N30/74A61K2236/331A61K2236/39A61K2236/51
Inventor 张志强刘天祎程立伟董晨虹方鑫周永康李蕊
Owner BEIJING KANGRENTANG PHARMA
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