Coated microgranules for stabilizing lactic acid bacteria

A technology for coating granules and lactic acid bacteria, which is applied in the directions of medical raw materials derived from bacteria, fixed on/in organic carriers, and applications, and can solve problems such as large time and high cost.

Inactive Publication Date: 2004-02-25
IL YANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method requires a lot of time and high cost, and has worse effects than the coating method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 (A) first coating

[0023] Seed Lactobacillus acidophilus

[0024] Lactobacillus bifidus

[0025]Streptococcus faecalis

[0026] = 1:1:1 (w / w / w) mixture 250g

[0027] Coating solution Sodium alginate 3g

[0028] Water 300ml (B) second coating

[0029] Coated granules of seeds (A) 253g

[0030] Coating solution Zein-DP (processed from zein extract) 50g

[0031] Cetanol 5g

[0032] 80% ethanol 500ml

[0033] Glycerin 5ml) to prepare the first coated granules

[0034] The lactic acid bacteria were suspended in a fluidized bed granulator (SFC-MINI, Freund Co., Japan) and simultaneously spray-coated with the above-mentioned first coating solution. The operating conditions of the granulator were adjusted to the values ​​given in Table 1 below. Specifically, the temperature of the lactic acid bacteria-containing powder in the granulator, that is, the temperature of the coated powder,...

Embodiment 3

[0051] The coated granules of the present invention were prepared according to the same procedure as in Example 1, except that the following materials were used. (A) First coating

[0052] Seed Lactobacillus acidophilus

[0053] Lactobacillus bifidus

[0054] Streptomyces faecalis

[0055] = 1:1:1 (w / w / w) mixture 250g

[0056] Coating solution Sodium alginate 3g

[0057] Water 300ml (B) second coating

[0058] Coated granules prepared from seeds (A) 253g

[0059] Coating Solution HPMCP 50g

[0060] Ethanol / acetone mixture (1 / 1, v / v) 700ml

Embodiment 4

[0062] The coated granules of the present invention were prepared according to the same procedure as in Example 1, except that the following materials were used. (A) First coating

[0063] Seed Lactobacillus acidophilus

[0064] Lactobacillus bifidus

[0065] Streptomyces faecalis

[0066] = 1:1:1 (w / w / w) mixture 250g

[0067] Coating Solution Eudragit L30D 300ml

[0068] water 150ml

[0069] Propylene glycol 9g

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PUM

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Abstract

The present invention relates to an enteric coated granule prepared by coating lactic acid bacteria-containing seed with a water-miscilble coating material and then, if desired, subjecting the first coated product to the second coating with a controlled-release coating material.

Description

technical field [0001] The present invention relates to enteric coated microparticles for better stabilization of lactic acid bacteria. In the specification of the present invention, the term "lactic acid bacteria" refers to bacteria beneficial to health, which are present in the human intestine and contribute to the active peristalsis of the intestine. Background technique [0002] The lactic acid bacteria ingested by the living body can prevent abnormal fermentation of food and activate intestinal function, thereby improving functional abnormality of the intestine such as constipation, diarrhea, etc. and maintaining health. In addition, adding lactic acid bacteria to feed can prevent gas accumulation, constipation, diarrhea, etc. caused by abnormal fermentation in the intestines of livestock that may be caused by repeated supply of the same feed, thereby ultimately improving meat quality. quality and contribute to the development of dairy farms. [0003] However, althoug...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/28A23C9/13A61K9/16A61K35/74A61K47/26A61K47/32A61K47/36A61K47/38A61K47/42A61P1/14
CPCA61K9/5042A61K35/747A61K9/5052A61K35/744A61K9/5073A61K9/00A61K9/5026A61K9/5036A61K35/745A61P1/14A23C9/13
Inventor 金东渊朴东雨全泓烈
Owner IL YANG PHARMA CO LTD
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