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Preparation method of Tylvalosin enteric coated granules

A technology of tylvalosin enteric and tylvalosin, which is applied in the field of preparation of tylvalosin enteric-coated granules, can solve the problems of poor curative effect, low bioavailability and the like, and achieve the effects of improving feed remuneration and achieving remarkable effects.

Inactive Publication Date: 2020-03-27
ZHENGZHOU DOURIN VETERINARY TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, because tivalamectin is unstable in gastric acid and has low bioavailability, the curative effect of drug mixing and administration is usually not good, which has become an urgent problem to be solved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation method of tyvanectin enteric-coated granules, comprising the following steps:

[0024] (1) Su granules are equipped with raw materials according to the following parts by weight: 75 parts of tyvanectin, 38 parts of dextrin, 75 parts of oral sugar, 10 parts of stevia, 5 parts of ethyl maltol, 85 parts of casing material, and 85 parts of filler , 15 parts of disintegrant and 80 parts of starch slurry;

[0025] (2) Mixing: Mix and pulverize the tivalamectin, dextrin, oral sugar, stevioside, ethyl maltol, and casing materials, and pass through a 90-mesh sieve; then place the mixed powder in high-efficiency wet granulation Add an appropriate amount of solvent into the machine, mix evenly with low stirring and low shearing, then high stirring and high shearing for an appropriate time, then add the filler, disintegrant, and 15wt% starch slurry, first low stirring and low shearing, then high stirring and high shearing Granulating and discharging to obtain soft ma...

Embodiment 2

[0029] A preparation method of tyvanectin enteric-coated granules, comprising the following steps:

[0030] (1) Su granules are equipped with raw materials according to the following parts by weight: 50 parts of tyvanectin, 50 parts of dextrin, 50 parts of oral sugar, 12 parts of stevioside, 4 parts of ethyl maltol, 100 parts of casing material, and 70 parts of filler , 20 parts of disintegrant and 60 parts of starch slurry;

[0031] (2) Mixing: Mix and pulverize the tivalamectin, dextrin, oral sugar, stevioside, ethyl maltol, and casing materials, and pass through a 90-mesh sieve; then place the mixed powder in high-efficiency wet granulation Add an appropriate amount of solvent into the machine, mix evenly with low stirring and low shearing, then high stirring and high shearing for an appropriate time, then add the filler, disintegrant, and 15wt% starch slurry, first low stirring and low shearing, then high stirring and high shearing Granulating and discharging to obtain so...

Embodiment 3

[0035] A preparation method of tyvanectin enteric-coated granules, comprising the following steps:

[0036] (1) Su granules are equipped with raw materials according to the following parts by weight: 100 parts of tyvanectin, 25 parts of dextrin, 100 parts of oral sugar, 8 parts of stevioside, 6 parts of ethyl maltol, 70 parts of casing material, and 100 parts of filler , 10 parts of disintegrant and 100 parts of starch slurry;

[0037] (2) Mixing: Mix and pulverize the tivalamectin, dextrin, oral sugar, stevioside, ethyl maltol, and casing materials, and pass through a 90-mesh sieve; then place the mixed powder in high-efficiency wet granulation Add an appropriate amount of solvent into the machine, mix evenly with low stirring and low shearing, then high stirring and high shearing for an appropriate time, then add the filler, disintegrant, and 15wt% starch slurry, first low stirring and low shearing, then high stirring and high shearing Granulating and discharging to obtain ...

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PUM

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Abstract

The invention belongs to the technical field of veterinary medicines, and particularly relates to a preparation method of Tylvalosin enteric coated granules. The preparation method comprises the following steps of (1) preparing Tylvalosin granules from: Tylvalosin, dextrin, orally-taken sugar, stevioside, ethyl maltol, a sausage casing material, a stuffing agent, a disintegrant and starch pulp; (2) performing material mixing: uniformly mixing the Tylvalosin with the dextrin, the orally-taken sugar, the stevioside, the ethyl maltol and the sausage casing material, performing crushing, performing screening to obtain mixed powder, adding an appropriate quantity of the solvent to the mixed powder, performing uniform mixing, adding the stuffing agent, the disintegrant and the starch pulp, and performing uniform mixing to prepare soft materials; and (3) performing granulation: making wet granule minipills from the prepared soft materials, and performing drying until the obtained Tylvalosin enteric coated granules are obtained. The prepared Tylvalosin enteric coated granules can be taken in groups, effective components of the Tylvalosin enteric coated granules are not destroyed by gastricacid and can safely reach intestines to be absorbed, and the feed conversion ratio can be notably increased.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a preparation method of tyvanectin enteric-coated granules. Background technique [0002] Tyvanectin is the third-generation macrolide drug for animals. It is the only drug that can really reach the bronchial cavity and kill mycoplasma. Its antibacterial potency is 5-10 times that of tylosin. Tilmicosin 2-5 times. The alkaline side chain possessed by tyvanectin can effectively change the intracellular pH value and inhibit the reproduction of PRRS virus, and is used for mycoplasma disease in livestock and poultry (swine panting disease, chicken slow breathing), pig PRRS, porcine proliferative enteritis , Infectious pleuropneumonia, streptococcal disease prevention and treatment. [0003] At present, because tivalamectin is unstable in gastric acid and has low bioavailability, the curative effect of drug mixing and administration is not good, which has bec...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/32A61K47/38A61K47/36A61K31/7048A61P31/04A61P11/06A61P31/14A61P1/00A61P11/00
CPCA61K9/1635A61K9/1652A61K31/7048A61P1/00A61P11/00A61P11/06A61P31/04A61P31/14
Inventor 胡功政王燕
Owner ZHENGZHOU DOURIN VETERINARY TECH
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