4 results about "Streptococcal disease" patented technology

The application relates to a protective antigen of streptococcus suis disease and application thereof, and belongs to the technical field of biological vaccines. The amino acid sequence shown in SEQ ID No. 1 provided in the application is used as a protective antigen of streptococcus suis disease. The protective antigen is obtained by codon optimization of the nucleotide sequence shown in SEQ ID No. 2, construction of an expression vector and prokaryotic expression, and the protective antigen is verified to be capable of providing good immune cross-protection for type 2 and type 7 streptococcus suis infection in different ways. The application scheme has important significance for research on a general vaccine candidate antigen of multiple serotypes of streptococcus suis and scientific prevention and control of the disease.

The application belongs to the technical field of Chinese herbal medicines, and particularly relates to a Chinese herbal medicine composition for resisting Streptococcus agalactiae, a preparation method and application thereof. Raw materials for preparing the Chinese herbal medicine composition include cortex mali and cumin. The Chinese herbal medicine composition is easy to obtain and simple to prepare, has no chemical residues, is not prone to drug resistance, has significant bacteriostatic activity on Streptococcus agalactiae, and can be applied to the prevention and treatment of Streptococcus agalactiae disease of fish such as tilapia.

The invention relates to the technical field of feed additives, in particular to a traditional Chinese medicine composition for preventing and treating streptococcus iniae diseases of humpback perches as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-15 parts of eucommia ulmoides, 10-15 parts of folium artemisiae argyi, 10 parts of radix angelicae, 10-13 parts of rhizoma zingiberis, 10-12 parts of liquorice, 7-9 parts of caulis spatholobi, 7-8 parts of herba ecliptae, 7-8 parts of radix ophiopogonis, 6-7 parts of poria cocos, 7-8 parts of hawthorn, 3-5 parts of radix aucklandiae, 3-4 parts of dendrobe, 3-5 parts of radix pulsatillae and 3-5 parts of radix puerariae. By feeding the traditional Chinese medicine composition provided by the invention, the weight gain rate of the humpback perches is increased by 20%, and the death rate of the humpback perches infected with streptococcus iniae is reduced by 10%.

There is currently a high demand for new therapeutic antibiotics with new mechanisms of action. Disclosed are two small molecules, tryglysin A and B, with novel chemical structures and potent antibiotic activity against a narrow spectrum of bacteria. This narrow spectrum of activity indicates the tryglysins could be working through a novel antibiotic mechanism of action. Due to this narrow spectrum, the tryglysins could be used as highly targeted therapeutics to treat or prevent disease without disturbing other important, “beneficial” bacteria within the human microbiome, which is a great improvement over virtually all other clinically used antibiotics that are broad-spectrum. The tryglysins are potent against several streptococcal pathogens, including Streptococcus pneumonia, the leading cause of pneumonia, and Streptococcus mutans, the primary causative agent of tooth decay and gum disease. The tryglycins may allow the development of therapeutics for the treatment and / or prevention of disease caused by these streptococci.