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Combined medicine emulsifiable paste for anesthesia, and preparation method thereof

A cream and drug technology, applied in the directions of mixing methods, anesthetics, drug combinations, etc., can solve the problems of skin allergic reaction, single component, redness and swelling reaction, etc. Effect

Active Publication Date: 2022-01-28
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Anesthesia drugs currently on the market have a single component and lidocaine can also cause skin allergic reactions, especially for patients with sensitive skin. When patients cannot tolerate lidocaine, it will cause more serious redness and swelling reactions

Method used

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  • Combined medicine emulsifiable paste for anesthesia, and preparation method thereof

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Embodiment 1

[0014] A combined drug cream for anesthesia, calculated in parts by mass, comprising 30-100 parts of lidocaine, 30-100 parts of prilocaine, 10-15 parts of pH regulator, 5-10 parts of soothing agent, emulsifier 20-35 parts, thickener 15-30 parts, menthol 1-25 parts, purified water 9000-9500 parts.

[0015] A preparation process for a combined drug cream for anesthesia, which is weighed according to the above-mentioned components and doses; first put 9000-9500 parts of purified water into the mixing equipment, and then add lidocaine 30- 100 parts, 30-100 parts of prilocaine, heated to 80° and stirred by stirring equipment until dissolved, after dissolving, add 5-10 parts of soothing agent, 20-35 parts of emulsifier, 15-30 parts of thickener, mint 1-25 parts of brain, continue to start the stirring equipment and stir for 10-30 minutes; add 10-15 parts of pH regulator to adjust the pH value of the solution in the mixing equipment to 6.0-8.0, continue to stir evenly, and then obtai...

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Abstract

The invention discloses a combined medicine emulsifiable paste for anesthesia, and a preparation method thereof. The combined medicine emulsifiable paste comprises, by mass, 30-100 parts of lidocaine, 30-100 parts of prilocaine, 5-10 parts of a soothing agent, 20-35 parts of an emulsifier, 15-30 parts of a thickening agent and 9000-9500 parts of purified water. The above medicinal composition disclosed by the invention has the effects of being small in micro-emulsion particle size, narrow in distribution, good in transdermal effect, quick in anesthesia effect, long in anesthesia maintenance time and capable of preventing cold vibration after anesthesia, and through the synergistic effect of all the components, the drug effect of lidocaine can be more fully exerted, so a prepared anesthetic has a better anesthetic effect, a patient is prevented from being hurt due to insufficient anesthesia, and the sensitization risk caused by lidocaine and prilocaine is reduced.

Description

technical field [0001] The invention relates to the technical field of anesthesia drugs, in particular to a combined drug cream for anesthesia and a preparation method thereof. Background technique [0002] Narcotic drugs refer to drugs that have an anesthetic effect on the central nervous system, are used continuously, abused or used irrationally, and are prone to physical and mental dependence, and can lead to addiction. However, when performing medical work, it is necessary to inject anesthesia drugs to the patient so as to facilitate the work of medical personnel. When anesthesia drugs play a role, the drug effect is poor, or the patient's tolerance is poor, so that the patient is injured due to insufficient anesthesia or other adverse reactions. Lidocaine-containing cream can be used for local cortical anesthesia. In recent years, many manufacturers have made lidocaine into ointment, which can penetrate the local mucous membrane and skin, and act on superficial nerve e...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K9/06A61P23/00B01F27/112B01F27/11B01F23/00B01F23/43A61K31/045B01F101/22
CPCA61K31/167A61K31/045A61K9/06A61P23/00A61K2300/00
Inventor 郭晓光张亚娟
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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