Particle separation device based on microfluidics

Abstract

The invention provides a particle separation device based on microfluidics, which is characterized in that on the basis of the microfluidics of bulk acoustic waves and slant angle acoustic streams of a polymethyl methacrylate (PMMA) material, the bulk acoustic waves are excited in the PMMA material through a lead zirconate titanate (PZT) transducer to form standing waves; and particles flowing through an inclined area are separated according to the size under the action of the sound field and resistance through a middle inclined area channel, which has a certain inclined angle with the PZT, in the microfluid channel. The design of the inclined angle channel allows higher throughput, is easier to manufacture in a large scale, and is firmer and more durable than a particle separation device based on a surface standing acoustic wave inclined angle.

Description

technical field [0001] The invention belongs to the technical field of particle separation, in particular to a particle separation device based on microfluidics. Background technique [0002] Complex fluid modules contain particles, cells, droplets, and other contamination particles. How to separate particles has become a key issue in many application fields, such as industrial applications, environmental evaluation, biochemical analysis, and clinical diagnosis. The separation method of standing surface acoustic wave is studied in the prior art. One of the limitations is that the standing surface acoustic wave needs to use the channel of polydimethylsiloxane (PDMS) material, which has the disadvantage of high attenuation and exists in large-scale applications. Create difficult questions. In addition, the channels of the PDMS material required for standing surface acoustic waves have strict channel height restrictions, resulting in disadvantages such as low throughput and a ...

AI Technical Summary

Problems solved by technology

The separation method of standing surface acoustic wave is studied in the prior art. One of the limitations is that the standing surface acoustic wave needs to use the channel of polydimethylsiloxane (PDMS) material, which has the disadvantage of high attenuation and exists in large-scale applications. create difficult problems

In addition, the channels of the PDMS material required for the application of standing surface acoustic waves have strict channel height restrictions, resulting in disadvantages such as low throughput and a narrow particle size range.

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