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Beta-nicotinamide mononucleotide and herbal extract microcapsule, preparation process and preparation device

A single nucleotide and preparation device technology, which is applied in the direction of microcapsules, capsule delivery, drug combination, etc., can solve problems such as low production efficiency, complex structure, and ineffective direct intake of β-nicotinamide mononucleotide , to achieve the effect of high charging efficiency, simple structure and excellent anti-aging effect

Pending Publication Date: 2022-02-01
江苏信佑生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to design a kind of β-nicotinamide mononucleotide and herbal medicine for the insignificant effect of direct intake of β-nicotinamide mononucleotide and the complex structure and low production efficiency of existing capsule preparation devices. Extract microcapsules, preparation process and preparation device

Method used

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  • Beta-nicotinamide mononucleotide and herbal extract microcapsule, preparation process and preparation device
  • Beta-nicotinamide mononucleotide and herbal extract microcapsule, preparation process and preparation device
  • Beta-nicotinamide mononucleotide and herbal extract microcapsule, preparation process and preparation device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 discloses a microcapsule of β-nicotinamide mononucleotide and herbal extract, the microcapsule includes a powdery material filled in the capsule, wherein the powdery material is composed of β-nicotinamide mononucleotide The powder and rosemary herbal extract crystalline powder are mixed in a weight ratio of 11:3. Specifically, the preparation process of microcapsules of β-nicotinamide mononucleotide and herbal extracts includes the following steps:

[0054] Step 1, crush rosemary and sieve it, add 1.2% bio-enzyme with a weight of 1.2% of the crushed and sieved material, and mix the two, wherein the bio-enzyme is a mixture of cellulase and pectinase at a ratio of 2:5 The enzyme, wherein the activity unit of the biological enzyme is 5000U / g, is mixed and added to the buffer, and then fermented at 46°C for 5 days.

[0055] Step 2, placing the fermented raw materials in a continuous countercurrent ultrasonic extractor, and adding ethanol solution for extraction. ...

Embodiment 2

[0061] Example 2 discloses a microcapsule of β-nicotinamide mononucleotide and herbal extract, the microcapsule includes a powdery material filled in the capsule, wherein the powdery material is composed of β-nicotinamide mononucleotide The powder and rosemary herbal extract crystalline powder are mixed at a weight ratio of 6:1. Specifically, the preparation process of microcapsules of β-nicotinamide mononucleotide and herbal extracts includes the following steps:

[0062] Step 1, crush and sieve rosemary, add 1.7% bio-enzyme with a weight of 1.7% of the crushed and sieved material, and mix the two, wherein the bio-enzyme is a mixture of cellulase and pectinase in a ratio of 1:2 The enzyme, wherein the activity unit of the biological enzyme is 5000U / g, is mixed and added to the buffer, and then fermented at 48°C for 3.5 days.

[0063] Step 2, placing the fermented raw materials in a continuous countercurrent ultrasonic extractor, and adding ethanol solution for extraction.

...

Embodiment 3

[0070] Example 3 discloses a preparation device for preparing microcapsules of β-nicotinamide mononucleotide and herbal extracts in the above-mentioned Examples 1 and 2. Please refer to the attached figure 2 And attached image 3 , the main components of the preparation device include a machine base 100 , a powder bin 200 , a station rotation switching mechanism 300 , a filling device 400 and a capsule receiving tank 500 . Reference attached Figure 4 And attached Figure 5 , the upper surface of the base 100 is provided with a bearing ring 101 communicating with the inner cavity of the base, and the bottom wall of the inner cavity of the base 100 is fixedly provided with a column 102 passing through the bearing ring 101 and extending out of the base 100 . The powder silo 200 in the present embodiment is fixedly arranged on the top of the column 102, and the lower end of the powder hopper 200 is provided with an auger feeder 201 (the internal structure of the auger feeder i...

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Abstract

The invention belongs to the technical field of capsule preparation, and particularly relates to a beta-nicotinamide mononucleotide and herbal extract microcapsule, a preparation process and a preparation device. The microcapsule comprises a powdery material filled in a capsule, wherein the powdery material is formed by mixing beta-nicotinamide mononucleotide powder and rosemary herb extraction crystal powder; and the preparation device comprises a machine base, a powder bin, a station rotation switching mechanism, a filling device and a capsule receiving groove. According to the beta-nicotinamide mononucleotide and herbal extract microcapsules disclosed by the invention, the beta-nicotinamide mononucleotide and the extracted rosmarinic acid powder are mixed in proportion, the beta-nicotinamide mononucleotide and the extracted rosmarinic acid powder are filled through the microcapsules after being mixed, and compared with single beta-nicotinamide mononucleotide, the mixed powder has a more excellent anti-aging effect; and all the steps of capsule shell feeding, powder filling, capsule cap sealing and automatic discharging are sequentially achieved through the preparation device, the structure of the whole device is simpler, and the production efficiency of capsules is improved.

Description

technical field [0001] The invention belongs to the technical field of capsule preparation, and in particular relates to a microcapsule of β-nicotinamide mononucleotide and herbal extract, a preparation process and a preparation device. Background technique [0002] β-nicotinamide mononucleotide is a naturally occurring bioactive nucleotide, which can be synthesized in the human body and can also be ingested from daily vegetables and meat. It is closely related to human immunity and metabolism. The function of β-nicotinamide mononucleotide in the body is mainly reflected by nicotinamide adenine dinucleotide, which is widely distributed in all cells and participates in thousands of biocatalytic reactions. In recent years, the anti-aging effect of nicotinamide adenine dinucleotide has attracted widespread attention in the scientific community. A large number of animal experiments have shown that after increasing the content of nicotinamide adenine dinucleotide, the aging organ...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/706A61K36/53A61K31/216A61P39/06A61J3/07
CPCA61K9/5089A61K31/706A61K36/53A61K31/216A61P39/06A61J3/074A61K2236/19A61K2300/00
Inventor 赵金龙陈俊辰王寅
Owner 江苏信佑生物有限公司
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