Chewing gum containing colloidal bismuth subcitrate

A technology of bismuth citrate and chewing gum, applied in the field of chewing gum preparations and chewing gum compositions

Inactive Publication Date: 2004-03-03
JOSMAN LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far no single agent has been shown to have this effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of embodiment 1 active reagent

[0040] Add bismuth citrate, citric acid and caustic potash in ammonia water at a certain temperature in a certain stoichiometric ratio. Check the solution for turbidity and, if necessary, add additional volumetric ammonia to clarify the solution. The solution was then filtered on a carbon bed and spray dried to obtain a free flowing powder material. Pack the product in a glass container that is insulated from air and moisture.

Embodiment 2

[0041] The preparation of embodiment 2 chewing gum

[0042] The chewing gum preparation method is briefly described below. The gum base was fully melted (at about 90°C) in a Bartender mixer, a jacketed mixer with sigma paddles. Drain the hot water from the jacket of the mixer and allow to cool, add the lecithin and mix well. Cool further to about 50°C, add liquid flavor and mannitol, mix until homogeneous. Colloidal bismuth subcitrate was dry blended in sorbitol and sodium citrate was blended in sorbo syrup. Add the sorbitol and sorbitol syrup blend to the chewing gum base. Cool the product to 35°C, add flavor and sweetener and mix until smooth. The product was drained from the mixing tank, rolled into sheets of uniform thickness, and measured to make chewing gum pieces weighing 2.5 grams each. Each piece of gum was individually wrapped in aluminum foil and placed in a plastic bag.

Embodiment 3

[0043] Example 3 Chewing Gum Compositions Containing CBS

[0044] Two chewing gums containing 50 mg of CBS were prepared according to Table 1 below. Both gum formulations were the same except that Formulation 2 contained sodium citrate to give a firmer structure while Formulation 1 did not.

[0045] Table 1

[0046] Chewing gum preparation (about 2.5g / piece) preparation 1 preparation 2CBS 50.0mg CBS 50.0mg crystalline sorbitol 910.0 crystalline sorbitol 910.0 gum base 575.0 gum base 575.0 sorbitol solution 500.0 sorbitol solution 500.0 mannitol 400.0 mannitol 400.0 peppermint oil 25.0 Peppermint Oil 25.0 Spray Dried Peppermint 12.5 Spray Dried Peppermint 12.5 T Grade Lecithin 10.0 T Grade Lecithin 10.0 Aspartame 10.0 Aspartame 10.0 Sodium Citrate 10.0 Total 2502.5mg Total 2492.5mg

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PUM

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Abstract

The invention provides a method of making a chewing gum composition containing a water soluble bulk portion, a water insoluble chewing gum base portion, a flavoring agent, and bismuth-containing compounds. The invention provides a method of making a bismuth-containing gum which when chewed multiple times per day, over the period of two weeks, is effective in reducing peptic ulcers by eradicating H. pylori. The chewing gum is also effective in eliminating forms of halitosis. The chewing gum does not have undesirable side effects, unpleasant taste and poor chewing characteristics.

Description

Background technique [0001] The present invention relates to chewing gum compositions containing active ingredients. More particularly, the present invention relates to finished chewing gum containing compounds for the treatment of ulcers and halitosis. [0002] Chewing gum compositions typically include a water soluble portion, a water insoluble chewing gum base portion and a water insoluble flavor. Additionally, the chewing gum composition may be formulated to deliver the active agent. These active agents can be various breath fresheners or agents such as laxatives, aspirin or nicotine. Delivery of these agents via a chewing gum carrier is ideal for people who have difficulty swallowing pills. In addition, the bad taste of some reagents can be masked by strong flavoring agents in chewing gum, thus chewing gum becomes an ideal carrier for delivering certain drugs. And some drugs can be absorbed directly into the bloodstream through the tissues in the mouth, making them ea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/00A61K8/19A61K8/42A61K8/49A61K8/64A61K8/88A61K8/97A61K9/68A61K31/28A61K31/29A61K31/43A61K31/44A61K31/485A61K33/24A61K38/16A61K45/06A61P1/00A61Q11/00A61Q17/00
CPCA61K8/88A61Q17/005A61K8/19A61Q11/00A61K38/164A61K31/29A61K8/42A61K31/44A61K31/43A61K45/06A61K8/49A61K8/64A61K31/485A61K8/494A61K33/245A61K8/97A61K31/28A61K9/0058A61P1/00A61P1/02A61K2300/00
Inventor N·K·阿塔尼卡
Owner JOSMAN LAB
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