Composition for controlling oil and strengthening skin barrier, preparation method and application thereof

A skin barrier and composition technology, which is applied to the skin barrier strengthening composition and its preparation, and oil control fields, can solve the problems of not taking into account the strengthening of the skin barrier and the adjustment of water-oil balance, the long-term effect is not outstanding, the immediate effect is not obvious, etc. The effect of strengthening the skin barrier, reducing the level of sebum secretion, excellent immediate effect

Pending Publication Date: 2022-02-11
科丝美诗(广州)化妆品有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current oil control products on the market have problems such as not obvious immediate effect, not outstanding long-term effect, irritation, adding powder by physical adsorption method will increase the burden on the skin, oil control does not take into account the strengthening of the skin barrier and the adjustment of water-oil balance, etc. The oil control effect is not good ideal

Method used

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  • Composition for controlling oil and strengthening skin barrier, preparation method and application thereof
  • Composition for controlling oil and strengthening skin barrier, preparation method and application thereof
  • Composition for controlling oil and strengthening skin barrier, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0034] The preparation method of oil control and strengthening skin barrier composition is as follows:

[0035] (1) Weigh the bark of Lvhua Ennan tomato, add 10 times the amount of butanediol to soak for 3 hours, extract by ultrasonic vibration, filter and collect the filtrate; the filtrate is concentrated under reduced pressure in a rotary evaporator, and the temperature is 50 , to obtain extract; add clarifying agent, stand at low temperature for 4 hours, filter; add 10 times the amount of deionized water, stir or ultrasonically mix to obtain Lvhua Ennan tomato bark extract.

[0036] (2) Weigh rosemary leaves, add 10 times the amount of butanediol to soak for 3 hours, extract by ultrasonic vibration, filter, and collect the filtrate; the filtrate is placed in a rotary evaporator and concentrated under reduced pressure at a temperature of 50°C to obtain Extraction; add clarifying agent, stand at low temperature for 4 hours, filter; add 10 times the amount of deionized water, ...

experiment example 1

[0044] Experimental example 1. Cytotoxicity test

[0045] MTT is a yellow powder chemical reagent widely used in the detection of cytotoxicity or cell proliferation. The detection principle is that succinate dehydrogenase in the mitochondria of living cells can reduce MTT to water-insoluble blue-purple crystalline formazan and deposit it. In cells, dead cells do not have this function. Dimethyl sulfoxide (DMSO) can dissolve formazan in cells, and the number of living cells can be judged according to the measured absorbance value. The specific experimental method is as follows:

[0046] 1×10 per well in a 96-well plate 4 100 μL of DMEM medium containing 10% bovine serum and 100 μL of human immortalized epidermal cells (HaCaT) were inoculated at the density of each cell, and replaced with serum-free medium after 24 hours of cultivation; , 200 μg / mL (diluted in water) of the oil control and skin barrier compositions prepared in the above-mentioned Examples 1-20 and Comparative ...

experiment example 2

[0053] Experimental example 2. Determination of inhibition of 5α-reductase activity

[0054] 5α-reductase can convert testosterone to DHT with the participation of reduced coenzyme II (NADPH). According to the ultraviolet-visible spectrophotometry, NADPH has a characteristic absorption peak at 340nm and the product after participating in the reaction has a characteristic absorption peak at 340nm, and the inhibition of each sample to 5α-reductase activity is judged by measuring the absorbance of the solution. The specific experimental method is as follows:

[0055] Add phosphate buffer solution with pH 7.4, 5α-reductase, testosterone, and NADPH to the test tube sequentially as shown in Table 3, measure the absorbance after mixing evenly, and measure the absorbance again after incubating at 37°C for 60 minutes, and calculate the blank Absorbance decrease value of control NADPH △A 0 ;

[0056] Add phosphate buffer with a pH of 7.4, 5α-reductase, testosterone, finasteride, or t...

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Abstract

The invention belongs to the technical field of daily cosmetics, and relates to a composition for controlling oil and strengthening skin barrier, a preparation method and application thereof. The composition comprises the following components in parts by weight: 1-6 parts of an Enantia chlorantha bark extract, 1-6 parts of a rosemary leaf extract, 1-5 parts of a lotus flower extract and 0.05-0.3 part of a plankton extract. According to the invention, the composition for controlling oil and strengthening skin barriernot only can inhibit the activity of 5 alpha-reductase, reduce the sebum secretion level and fundamentally solve the problem of oil production, but also can inhibit lipid peroxidation and strengthen the skin barrier, not only has a long-term oil control effect, but also shows an excellent instant effect; and by means of oil control, oxidation resistance and skin barrier enhancement, the skin gets rid of vicious circle of hypersebum secretion-lipid peroxidation-skin barrier damage, and the healthy state of water-oil balance is maintained.

Description

technical field [0001] The invention belongs to the technical field of daily cosmetics, and relates to a composition for oil control and skin barrier strengthening, its preparation method and application. Background technique [0002] Exogenous factors such as ultraviolet rays, stress, diet, sleep, and environment damage the skin barrier function, so the skin secretes sebum to maintain the normal barrier function. At the same time, sebum also has the functions of regulating body temperature, moisturizing, and transporting. However, excessive sebum secretion based on genetics, hormones or other exogenous factors will bring about negative problems such as inflammation, pore clogging, and acne, which will cause troubles for people with oily skin and sensitive skin. Cosmetics with barrier effect restore the skin to a healthy, natural and translucent state. [0003] The current oil control products on the market have problems such as not obvious immediate effect, not outstanding...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/25A61Q19/00A61Q17/04A61Q19/08A61Q19/10A61Q1/02
CPCA61K8/9789A61K8/25A61Q19/008A61Q17/04A61Q19/00A61Q19/08A61Q19/10A61Q1/02A61K2800/782A61K2800/592A61K2800/5922
Inventor 施丽娟周秋娜姚清金成勇金荣熙金延埈
Owner 科丝美诗(广州)化妆品有限公司
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