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Application of peptide-zinc chelate in anti-allergic product

A zinc chelate, anti-allergic technology, applied in the field of functional peptides, can solve problems such as limited application scope, and achieve the effect of enhancing regulation function and enhancing anti-allergic properties

Pending Publication Date: 2022-02-15
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are patents disclosing the preparation method of oyster active peptide-zinc chelate, but it is only used in health food such as zinc nutritional supplements, and the scope of application is relatively limited. This kind of chelate still has more physiological functions to be developed. excavate

Method used

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  • Application of peptide-zinc chelate in anti-allergic product
  • Application of peptide-zinc chelate in anti-allergic product
  • Application of peptide-zinc chelate in anti-allergic product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Hyaluronidase inhibition experiment of embodiment 1 oyster peptide-zinc chelate

[0025] 1. Preparation of oyster peptide-zinc chelate

[0026] (1) Preparation of mixed solution: Weigh 1.8g of oyster peptide powder and 0.09g of zinc sulfate solid with an electronic balance, add them to a beaker respectively, and add water to prepare a 30mL solution.

[0027] (2) Chelation: Put the prepared mixed solution into a water bath for heating at a temperature of 50° C. for 1 hour. The heated solution was taken out and cooled to room temperature.

[0028] (3) Precipitation of chelates: Pour the prepared 150mL absolute ethanol (volume of ethanol: volume of mixed solution = 5:1) into an empty beaker, pour the cooled mixed solution, mix the two, and the chelates Precipitate. After that, put them into four 50mL centrifuge tubes for balance.

[0029] (4) Centrifugation: After the 4 centrifuge tubes are put into the centrifuge symmetrically, adjust the parameters of centrifugation ...

Embodiment 2

[0061] Example 2 RBL-2H3 cell model experiment of oyster peptide-zinc chelate

[0062] 1. Preparation of oyster peptide-zinc chelate under optimal chelation conditions

[0063] (1) Preparation of mixed solution: Weigh 1.8g of oyster peptide powder and 0.09g of zinc sulfate solid with an electronic balance, add them to a beaker respectively, and add water to prepare a 30mL solution.

[0064] (2) Chelation: Put the prepared mixed solution into a water bath for heating at a temperature of 50° C. for 1 hour. The heated solution was taken out and cooled to room temperature.

[0065] (3) Precipitation of chelates: Pour the prepared 150mL absolute ethanol (volume of ethanol: volume of mixed solution=5:1) into an empty beaker, pour the cooled mixed solution, mix the two, and the chelates Precipitate. After that, put them into four 50mL centrifuge tubes for balance.

[0066] (4) Centrifugation: After the 4 centrifuge tubes are put into the centrifuge symmetrically, adjust the param...

Embodiment 3

[0078] Example 3 Passive skin allergic reaction test of oyster peptide-zinc chelate

[0079] 1. Preparation of oyster peptide-zinc chelate under optimal chelation conditions

[0080] (1) Preparation of mixed solution: Weigh 1.8g of oyster peptide powder and 0.09g of zinc sulfate solid with an electronic balance, add them to a beaker respectively, and add water to prepare a 30mL solution.

[0081] (2) Chelation: Put the prepared mixed solution into a water bath for heating at a temperature of 50° C. for 1 hour. The heated solution was taken out and cooled to room temperature.

[0082] (3) Precipitation of chelates: Pour the prepared 150mL absolute ethanol (volume of ethanol: volume of mixed solution=5:1) into an empty beaker, pour the cooled mixed solution into it, mix the two, and the chelates Precipitate. After that, put them into four 50mL centrifuge tubes for balance.

[0083] (4) Centrifugation: After the 4 centrifuge tubes are put into the centrifuge symmetrically, ad...

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Abstract

The invention provides application of a peptide-zinc chelate in an anti-allergic product, and belongs to the technical field of functional polypeptide application. The oyster peptide powder and zinc sulfate are chelated under a certain condition to prepare the oyster peptide-zinc chelate, and the results of an in-vitro hyaluronidase inhibition experiment, an RBL-2H3 cell model detection beta-hexosaminidase release experiment and an animal and crowd experiment show that the oyster peptide-zinc chelate can effectively regulate type I anaphylaxis and exert an anti-allergic physiological function, and is expected to be applied to preparation of anti-sensitization products and enhancement of organism immunity. The application of the peptide-zinc chelate in preparation of the anti-allergic product is provided for the first time, the application range of functional polypeptide is widened, a new thought is provided for improving the anti-allergenicity of the anti-allergenicity product, and the peptide-zinc chelate has important social and economic significance.

Description

technical field [0001] The invention relates to the technical field of functional polypeptides, in particular to the application of peptide-zinc chelates in antiallergic products. Background technique [0002] Allergic reaction refers to the response of tissue damage or dysfunction that occurs when the immune body is stimulated again by the same antigen. In recent years, the incidence of allergic diseases has continued to rise. It has been reported that the prevalence of allergies in the world is as high as 22%. In my country, more than 200 million people suffer from allergic diseases, and the prevalence exceeds 10%. However, the current public Awareness of the disease is still relatively lagging behind. Allergic diseases can cause symptoms such as airway obstruction, central nervous system disorder, skin redness, swelling and itching, which seriously affect the work and life of patients. [0003] The current research on anti-allergic ingredients has attracted the attention...

Claims

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Application Information

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IPC IPC(8): A23L33/165A23L33/18A61K38/02A61K33/30A61P37/08A61P17/00A61P3/02A61K8/64A61K8/27A61Q19/00
CPCA23L33/165A23L33/18A61K38/02A61K33/30A61P37/08A61P17/00A61P3/02A61K8/64A61K8/27A61Q19/005A23V2002/00A61K2800/782A23V2200/304A23V2250/1642A23V2250/55A61K2300/00
Inventor 车会莲曾冰蕙石晓楠刘桂蓉郝梦真姜玉池李苏婉韩诗雯
Owner CHINA AGRI UNIV
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