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Application of rabdosia lophanthide in prevention or treatment of alcohol dependence

A technology of alcohol dependence and Xihuangcao, which is applied in the field of biomedicine to achieve the effect of reducing alcohol preference, improving anxiety-like behavior, and preventing alcohol dependence

Active Publication Date: 2022-03-04
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no research on the alcohol dependence of Xihuangcao

Method used

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  • Application of rabdosia lophanthide in prevention or treatment of alcohol dependence
  • Application of rabdosia lophanthide in prevention or treatment of alcohol dependence
  • Application of rabdosia lophanthide in prevention or treatment of alcohol dependence

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Preparation of the water extract of Xihuangcao: Take 100g of dried Xihuangcao whole herb, add 600ml of water to decoct twice, each decocting time is 1h, combine the decoctions, and concentrate to a thick consistency with a relative density of 1.1-1.25 (50-60°C). Ointment, standby (1g Xihuangcao crude drug is equivalent to 0.1g Xihuangcao extract).

[0063] 1. Experimental reagents

[0064] Alcohol: (intraperitoneal injection dose 2g / kg, concentration 15%);

[0065] 0.9% normal saline;

[0066] The water extract of Xihuangcao prepared in Example 1 (modeling is intraperitoneal injection, treatment is intragastric administration).

[0067] 2. Experimental animals and grouping

[0068] C57BL / 6J mice, male, 150, at least 60 mice that can be used for the experiment were screened out by conditional place preference test (CPP), divided into 6 groups, 10 in each group; followed by normal control group (normal saline) , simple Xihuangcao group (Xihuangcao crude drug 1.0g / kg+n...

Embodiment 2

[0103] The preparation method of the ethanol extract of Xihuangcao: take a certain amount of Xihuangcao, add 20 times the amount of 70% ethanol, extract for 25 minutes, filter, and concentrate under reduced pressure.

Embodiment 3

[0105] The present embodiment provides a product for preventing and treating alcohol dependence. The preparation method is as follows: take 100g of the whole herb dry product of Xihuangcao and 100g of sweet-scented osmanthus (dried product), add 1000ml of water to decoct twice, each decoction time is 1h, and the decoctions are combined. Concentrate, that is.

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PUM

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Abstract

The invention relates to application of rabdosia lophanthide in prevention or treatment of alcohol dependence. The research discovers for the first time that rabdosia serra can significantly reduce the position preference effect of mice on alcohol, disturb the formation of alcohol-induced behavior sensitization, reduce the drinking amount of the mice, reduce the alcohol preference degree and effectively improve the anxiety behavior of the mice after acute alcohol withdrawal, and does not affect alcohol absorption and metabolism; the composition has an excellent prevention and treatment effect on alcohol dependence.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of Xihuangcao in the prevention or treatment of alcohol dependence. Background technique [0002] Alcohol has a strong psychoactive effect. After drinking, it can make people feel comfortable, forget troubles, relax the whole body, relieve fatigue and boost the spirit. Alcohol is recognized as a "social lubricant". In modern society, there are more and more interpersonal communication and entertainment, and the consumption of alcohol has increased dramatically. However, long-term unrestrained drinking inevitably leads to alcohol-related health problems such as acute alcoholism (drunkenness), alcoholic liver disease, and alcohol dependence (addiction). Acute alcoholism refers to the abnormal body function of the drinker after a large amount of alcohol intake at one time. , the initial manifestation is fatty liver, and then can develop into alcoholic hepatitis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K36/815A61P25/32A23F3/34A23L33/105
CPCA61K36/53A61K36/63A61K36/725A61K36/42A61K36/815A61P25/32A23F3/34A23L33/105A61K2236/331A61K2236/333A61K2236/39A23V2002/00A61K2300/00A23V2200/334A23V2250/21A23V2300/14A23V2300/50A23V2300/10
Inventor 郭海彪李淑如李楚源王德勤邹江林
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE