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Application of HDS in predicting prognosis of gastric cancer patient, guiding postoperative adjuvant chemotherapy and predicting curative effect of immunotherapy

A technology for gastric cancer and patients, applied in the field of biomedicine, can solve problems such as difficult to precisely control changes in TME

Active Publication Date: 2022-03-04
PEOPLES HOSPITAL PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, different types of HDACs are heterogeneous in regulating TME cell infiltration levels, and it is difficult for a single molecule or class of molecular targeted inhibitors to precisely control changes in the TME

Method used

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  • Application of HDS in predicting prognosis of gastric cancer patient, guiding postoperative adjuvant chemotherapy and predicting curative effect of immunotherapy
  • Application of HDS in predicting prognosis of gastric cancer patient, guiding postoperative adjuvant chemotherapy and predicting curative effect of immunotherapy
  • Application of HDS in predicting prognosis of gastric cancer patient, guiding postoperative adjuvant chemotherapy and predicting curative effect of immunotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Example 1 Calculation of histone deacetylase score (histone deacetylase score, HDS)

[0105] NMF cluster analysis was performed on the HDAC expression profiles of the ACRG cohort (also known as the GSE62254 cohort, which contains a large amount of complete clinical information), one of the largest datasets in GEO. It can be divided into three stable isoforms (HDAC clusters A, B and C) ( figure 1 ). The Limma software package was used to identify significantly differentially expressed genes between different HDAC clusters, P 1, and the high expression of this type of gene indicated poor prognosis, and this type of gene was defined as type B gene. Based on the expression of the above 103 genes, an HDS was constructed using principal component analysis (PCA) to quantify the score of each patient, and the first principal component (principal component 1) was used as the feature score. Use a method, such as GGI to define:

[0106] HDS=

[0107] PC1i represents the fea...

Embodiment 2

[0113] Example 2 Correlation analysis between HDS and prognosis of gastric cancer

[0114] Gastric cancer samples in the ACRG cohort were divided into high HDS group and low HDS group according to the median, and the median was 0.08. The results showed that the high HDS group had a longer survival time than the low HDS group ( figure 2 in A).

[0115] Gastric cancer samples in the TCGA cohort were divided into high HDS group and low HDS group according to the median, with a median of 0.78. The results showed that the prognosis of low HDS was worse than that of high HDS ( figure 2 in B).

[0116] Analyzing the prognosis of high HDS and low HDS patients in different GEO cohorts, gastric cancer samples were divided into high HDS group and low HDS group according to the median, the median of GSE1545 was 0.65, the median of GSE34942 was 0.75, and the median of GSE57303 was 0.69GSE84437 The median is 0.106 ( image 3 ).

[0117] The above results indicated that HDS is reliable...

Embodiment 3

[0118] Example 3 Correlation analysis between HDS and the effect of immunotherapy in patients with gastric cancer

[0119] To elucidate the relationship between HDS and TME, the expression of HDS in six gastric cancer cohorts (TCGA-STAD, GSE15459, GSE34942, GSE57303, GSE62254, and GSE84437) was analyzed in relation to antigen presentation-related molecules, co-stimulatory molecules, co-inhibitory molecules, and angiogenesis Molecular correlations. It was found that HDS was positively correlated with the expression of most antigen-presenting molecules ( Figure 4 ), suggesting that the antigen presentation ability of patients with high HDS is significantly higher than that of patients with low HDS, and their ability to recognize and kill tumor cells in vivo is stronger. Further analysis found that HDS was positively correlated with the expression of co-stimulatory and co-inhibitory molecules ( Figure 4 ), suggesting that patients with high HDS have higher immunogenicity, but...

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Abstract

The invention discloses application of HDS in predicting prognosis of gastric cancer patients, guiding postoperative adjuvant chemotherapy and predicting the curative effect of immunotherapy. 103 genes related to gastric cancer prognosis are obtained through screening, an HDS score is constructed based on a PCA method, and analysis results prove that gastric cancer patients in a high HDS group have longer survival time than gastric cancer patients in a low HDS group; high-HDS gastric cancer patients are more suitable for immunotherapy; and patients with stage II low-HDS gastric cancer gain more benefits from postoperative chemotherapy than patients with high-HDS gastric cancer. The HDS evaluation system provides a new method for predicting prognosis of gastric cancer and selecting postoperative adjuvant chemotherapy regimens and immunotherapy regimens, and has a good clinical application prospect.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of HDS in predicting the prognosis of gastric cancer patients, guiding postoperative adjuvant chemotherapy and predicting the curative effect of immunotherapy. Background technique [0002] Gastric cancer is a common malignant tumor of the digestive tract. According to the 2020 global cancer statistics, the morbidity and mortality of gastric cancer have ranked fifth and fourth among malignant tumors, causing a huge economic burden to the society. Current treatments for gastric cancer include surgery combined with radiotherapy, chemotherapy, or targeted drug therapy. Although the prognosis of patients is gradually improving, the results are still not satisfactory. Therefore, in-depth exploration of the factors affecting the treatment and prognosis of gastric cancer and the development of new clinical treatment strategies are the primary tasks to improve the prognosis of g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G16B30/00G16B40/00
CPCC12Q1/6886G16B30/00G16B40/00C12Q2600/118C12Q2600/158C12Q2600/106
Inventor 申占龙林易霖叶颖江王杉
Owner PEOPLES HOSPITAL PEKING UNIV
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