Synthesis method of 1, 2, 3-triazole quinoxalinone derivative

Abstract

The invention belongs to the technical field of organic synthesis and medicines, and particularly relates to a synthesis method of a 1, 2, 3-triazole quinoxalinone derivative. Under ruthenium catalysis, a quinoxaline ketone derivative and a diazonium trivalent iodine reagent are used as raw materials, under blue light irradiation, stirring is performed in a solvent, and a reaction is performed at room temperature to obtain the 1, 2, 3-triazole quinoxaline ketone derivative. By using the method provided by the invention, the 1, 2, 3-triazole quinoxalinone derivative can be obtained by reacting for 10-15 hours at room temperature, and the yield is 66-82%. According to the reaction, the 1, 2, 3-triazole quinoxalinone derivative is simply, conveniently and rapidly synthesized by adopting simple and easily available raw materials under the conditions of ruthenium catalysis and blue light irradiation, and a novel simple, efficient and mild synthesis method is provided for synthesizing the 1, 2, 3-triazole quinoxalinone derivative.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis and medicine, in particular to a synthesis method of 1,2,3-triazolequinoxalinone derivatives. Background technique [0002] Heterocyclic compounds are the largest class of organic compounds, which are commonly found in drug molecules. Heteropolycyclic compounds, especially 1,2,3-triazolequinoxalinone derivatives and their similar tricyclic systems, have shown strong biological activities, such as G-protein coupled hydrochloric acid receptor 109A antagonists, diazepam receptor inhibitors, etc. [(a) Sharma, S.; Sharma, P.K.; Kumar, N.; Dudhe, R. Pharma. Chemica., 2010, 2, 253. (b) Khalilullah, H.; Ahsan, M.J.; Hedaitullah, M.; Khan, S.; Ahmed, B. Mini-Rev. Med. Chem., 2012, 12, 789]. However, there are few reports on the synthesis of these structures, and the reported traditional methods have limitations such as many steps, narrow substrate universality, and low yields. [0003] At pre...

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However, there are few reports on the synthesis of these structures, and the reported traditional methods have limitations such as many steps, narrow substrate universality, and low yields.

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