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Application of D-ribose in preparation of medicine or food for improving medicine-induced cardiotoxicity

A cardiotoxicity, ribose technology, applied in the field of medicine, can solve the problem of reduction in the number of cardiomyocytes, not fully elucidated, etc.

Pending Publication Date: 2022-03-22
HAIMEN PINSHANG MEDICINE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As a highly differentiated terminal cell, cardiomyocytes stop dividing and proliferating after birth, and their death will lead to a decrease in the number of cardiomyocytes, which will cause changes in the structure and function of the heart. DOX-induced cardiomyocyte death is a key factor in the development of heart diseases. The key, however, so far the mechanism of action of DOX cardiotoxicity has not been fully elucidated

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  • Application of D-ribose in preparation of medicine or food for improving medicine-induced cardiotoxicity
  • Application of D-ribose in preparation of medicine or food for improving medicine-induced cardiotoxicity
  • Application of D-ribose in preparation of medicine or food for improving medicine-induced cardiotoxicity

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Embodiment Construction

[0026] The objects, features and effects of the present invention will be further described below in conjunction with the appended claims.

[0027] Experimental design and grouping: 40 ICR male mice randomly divided into: normal control group (CON), doxicin group (DOX), low dose D-rib glucose (LDR) group and high dose D-rib sugar (HDR) group, Ten 10 each group, the processing of each group of mice is as follows:

[0028] Normal control group (CON): mouse abdominal injection of physiological saline;

[0029] Dooricin group (DOX): mouse intraperitoneal injection of doxorubicin 15mg / kg;

[0030] Low-dose D-Ribu (LDR) Group: D-Nuclear sugar 0.9mg / kg, once a week in the morning and evening, the mice were injected 15mg / kg in mice.

[0031] High dose D-ribbuly (HDR) group: D-ribose 1.8 mg / kg, once a week in the morning and evening, the mice were injected with arominum 15 mg / kg.

[0032] At the end, the weight of each treatment group was tested in each treatment group, and the l...

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Abstract

The invention discloses an application of D-ribose in preparation of drugs or food for improving drug-induced cardiotoxicity, in particular to an application in preparation of drugs or food for improving cardiotoxicity caused by anti-cancer drug adriamycin. The new application of the D-ribose disclosed by the invention provides a basis for research and development of new drugs and tumor nutrition preparations.

Description

Technical field [0001] The present invention belongs to the field of medical technology, and more particularly to a D-ribose in the preparation of the application of improved pharmaceutical cardiac drugs or foods. Background technique [0002] Doxorubicin, Dox is a clinically used high-efficiency green onion anti-tumor drug for treating blood system tumors and solid tumors such as acute leukemia, lymphoma, breast cancer, gastric cancer, soft tissue sarcoma and ovarian cancer. Tumor. However, in the clinical application, it also has toxic effects on normal cells, especially irreversible heart toxicity. The clinical manifestations are cardiac function, expandable myocardial disease, myocarditis or congestive heart failure. This not only greatly affects the patient's quality of life, but also clinical application of doxorubicin. Therefore, looking for a substance that effectively relieves its cardiac toxicity is a problem in clinical needs. [0003] D-ribose is a five-carbonate suga...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7004A61K31/704A61P9/00A61P35/00A61P3/02
CPCA61K31/7004A61K31/704A61K9/0053A61K9/0019A61P9/00A61P35/00A61P3/02A61K2300/00
Inventor 温敏王正平肖爱爱韩军
Owner HAIMEN PINSHANG MEDICINE SCI & TECH