Microporous capillary tube-based liquid drop generation device and preparation method thereof
A droplet generation and capillary technology, applied in the field of microfluidics, can solve the problems of shortening the equipment manufacturing process, long preparation cycle, and high technical threshold, and achieve the effects of simple and effective device structure, reduced equipment cost, and high technical threshold
Active Publication Date: 2022-03-22
INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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[0005]
In view of this, the embodiment of the present invention provides a microporous capillary-based droplet generation device and its preparation method, which can reduce equipment cost, shorten the equipment manufacturing process, and reduce manual operations, and solve the problem of complex procedures and problems of traditional microfluidic chip solutions. Disadvantages such as long preparation cycle, high production cost and high technical threshold
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[0066] The embodiment of the present invention provides a method of applying a microfluidic droplet according to an embodiment of the above apparatus. Figure 4 Methods include:
[0067] The continuous phase is loaded into the first syringe, and the output of the first syringe is attached to the input of the continuous phase transfer pipe;
[0068] The discrete phase sample is loaded into the second syringe, and the output of the second syringe is connected to the input of the microporous capillary;
[0069] Connect the sample collection container to the output of the focus capillary;
[0070] According to the multi-channel injection pump, the piston of the first syringe and the piston of the second syringe are simultaneously driven, so that the continuously sample flowing into the microporous flow channel of the microporous capillary and the discrete phase flow into the mainstream passage of the microporous capillary, in the microporous flow channel And mainstream convergence gene...
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Abstract
The invention discloses a liquid drop generation device based on a microporous capillary tube and a preparation method thereof, and provides a liquid drop generation device based on capillary tubes which already meet industrial specification standards and comprise a stainless steel capillary tube, a capillary quartz tube and a polymer capillary tube (polytetrafluoroethylene, polyether-ether-ketone, fluorinated ethylene propylene, rubber, silica gel and the like), and the liquid drop generation device is obtained by performing secondary laser ablation processing on the capillary tubes. And a micro-channel structure required by flowing of the focused flow is formed. A standardized technological process is formulated, core processing equipment only needs one laser marking machine, the equipment cost is reduced, the working procedure is shortened, the automation degree is high, manual operation is reduced, the defects that a traditional micro-fluidic chip scheme is complex in working procedure, long in preparation period, high in production cost, high in technical threshold and the like are overcome, and the method can be widely applied to the technical field of micro-fluidic control.
Description
Technical field [0001] The present invention relates to the field of microfluidic techniques, in particular, a droplet generating apparatus based on a microporous capillary and a preparation method thereof. Background technique [0002] Microfluidic technology is a technology that precisely controls micro-calibratic fluid, with a small amount of small capacity, miniature volume, low energy consumption. [0003] Droplet microfluidic control is one of the most important branches in microfluidic techniques, which generates and manipulate discrete microlicids through non-mismammous multiphase flow in the microchannel. Droplet microfluidic technology has the advantages of low reagents, fast response speed, high analysis and flux, has become a widely used multi-function tool. [0004] Traditional microfluidic technology is mainly implemented on a chip laboratory (Lab-on-a-chip), and microfluidic chip requires semiconductor micro-tank processing technology such as photolithography, etch...
Claims
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IPC IPC(8): B01L3/02
CPCB01L3/0268
Inventor 龚尧
Owner INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI