Murine animal experiment method for orthodontic distal movement of central incisor of upper jaw

Abstract

The invention discloses a mouse experiment method for orthodontic distal moving upper anterior teeth. The mouse experiment method comprises the following steps: S1, preparing an orthodontic distal moving upper anterior tooth retention groove: preparing the retention groove of about 0.08 mm in a physiological range of the thickness of enamel on the lip side of the upper anterior teeth; and S2, establishing a distal movement model of the upper anterior teeth of the mouse by using shape memory characteristics of the orthodontic nickel-titanium wire and an orthodontic ligation technology. The invention successfully constructs a stable, tissue-injury-free and simple mouse anterior tooth orthodontic movement model on the basis of a clinically common nickel-titanium wire and ligation technology. The mouse orthodontic tooth movement model effectively fills the blank that no mouse orthodontic tooth movement model capable of meeting experimental requirements exists at the present stage, the dilemma that animal experimental mechanism exploration is difficult to carry out due to the fact that no effective animal model guarantee exists is solved to a great extent, and the difficulty and complexity of related experiments are reduced to a certain extent; the orthodontic force is continuously distributed on teeth, clinical orthodontic behaviors are effectively simulated, and the orthodontic device can be popularized and used on a large scale.

Description

technical field [0001] The invention relates to the technical field of animal experiments, more specifically, the invention relates to a mouse animal experiment method for orthodontic distally moving maxillary central incisors. Background technique [0002] At present, with the improvement of living and aesthetic standards, more and more people choose orthodontic treatment to correct maxillofacial deformities such as uneven dentition, protrusion and recession. The core of orthodontics lies in the controllable movement of teeth in the collarbone. For this reason, many scholars have conducted a lot of research on tooth movement. There are many factors that affect tooth movement, and the influencing mechanisms are also different. Some implementation measures cannot be directly studied on humans. Therefore, animal experiments have become one of the basic experimental methods for orthodontic tooth movement research. [0003] The results of animal experiments are based on well-es...

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Problems solved by technology

According to domestic reports, the posterior teeth are moved forward by bonding the steel wire at the end of the spring to the posterior occlusal surface. The relay does not satisfy the requirement of the posterior teeth moving forward, and the successful evidence of the model is insufficient, and there are many doubts about the design, so the model experiment cannot be repeated

Foreign reports have used ligature wire to pass through the posterior gums to wrap around the neck of the posterior teeth and connect the springs to move the posterior teeth forward. From the perspective of the anatomical structure of the posterior teeth of mice, this design is also unreasonable, and the tissue damage is great, so it is difficult to repeat the experiment; and due to the small The mouth of the mouse is narrow, and it is laborious to pass the stainless steel ligature wire between the first molar and the second molar, which affects the smooth progress of the experiment

In addition, in terms of periodontal, the orthodontic device is also prone to cause gingival inflammation of the first molar and alveolar bone resorption

Although foreign models of using a tooth divider to move the posterior teeth of mice can move the posterior teeth without tissue damage, it is difficult to meet the experimental needs due to the rapid mechanical attenuation of the tooth divider and the poor stability of the distance rebound after movement.

The anterior tooth movement model is only reported in the rat model, and its damage is large. At present, the orthodontic tooth movement model of the mouse anterior teeth is almost lacking

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