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Wild honeysuckle flower total saponin as well as extraction method and application thereof

An extraction method and a technology of silver flower, which are applied in pharmaceutical formulations, medical preparations containing active ingredients, digestive systems, etc., can solve the problems of difficult recovery, long production time, unsuitable for promotion, etc., and achieve high utilization rate of raw materials, The effect of reducing purification steps, cost and industrial energy consumption

Pending Publication Date: 2022-04-01
亿利耐雀生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method produces a large amount of waste water containing organic reagents, which is not easy to recycle, and the production takes a long time, so it is not suitable for promotion

Method used

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  • Wild honeysuckle flower total saponin as well as extraction method and application thereof
  • Wild honeysuckle flower total saponin as well as extraction method and application thereof
  • Wild honeysuckle flower total saponin as well as extraction method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 500g of Jasmine Japonica and add 6.5L of water to immerse for 0.5h, then carry out reflux extraction, the extraction temperature is 75°C, the number of extractions is 3 times, and each extraction time is 1 hour. The solid-liquid ratio of the first reflux extraction is 1:13, and the solid-liquid ratio of the second reflux extraction and the third reflux extraction are both 1:10.

[0032] After filtering the extracts, combine the filtrates; properly concentrate the filtrates to 1 / 10 of the original volume; then elute the filtrates with resin, wash with water first, then wash with 30% ethanol, 70% ethanol, and 95% ethanol in sequence take off.

[0033] Using vacuum decompression concentration method, the vacuum degree is 0.08 MPa, the concentration temperature is 70° C., and the eluate is concentrated to dryness to obtain 61 g of total saponins from Jasmine Japonica. Yield 12.2%.

Embodiment 2

[0035] Take 500g of Jasmine Japonica and add 7.5L of water to immerse for 0.5h, then carry out reflux extraction, the extraction temperature is 75°C, the number of extractions is 2 times, and each extraction time is 1 hour. The solid-liquid ratio of the first reflux extraction is 1:13, and the solid-liquid ratio of the second reflux extraction and the third reflux extraction are both 1:10.

[0036] After filtering the extracts, combine the filtrates; properly concentrate the filtrates to 1 / 10 of the original volume; then elute the filtrates with resin, wash with water first, then wash with 30% ethanol, 70% ethanol, and 95% ethanol in sequence take off.

[0037] The eluate was concentrated to dryness by using a vacuum decompression concentration method with a vacuum degree of 0.08 MPa and a concentration temperature of 70° C. to obtain 58 g of total saponins from Jasmine Japonica. Yield 11.6%.

Embodiment 3

[0039] Take 500g of Jasmine Japonica and add 7.5L of water to immerse for 0.5h, then carry out reflux extraction, the extraction temperature is 95°C, the number of extractions is 2 times, and each extraction time is 1 hour. The solid-liquid ratio of the first reflux extraction is 1:13, and the solid-liquid ratio of the second reflux extraction and the third reflux extraction are both 1:10.

[0040] After filtering the extracts, combine the filtrates; properly concentrate the filtrates to 1 / 10 of the original volume; then elute the filtrates with resin, wash with water first, then wash with 30% ethanol, 70% ethanol, and 95% ethanol in sequence take off.

[0041] Using vacuum decompression concentration method, the vacuum degree is 0.08 MPa, the concentration temperature is 70° C., and the eluate is concentrated to dryness to obtain 67 g of total saponins of Jasmine Japonica. Yield 13.4%.

[0042] 2. Content detection

[0043] Content detection by high performance liquid chro...

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Abstract

The invention provides lonicerae flos total saponins as well as an extraction method and application thereof. The lonicera confusa total saponin is prepared by the following steps: adding lonicera confusa into water for soaking, and then carrying out reflux extraction; the solid-liquid ratio of the lonicerae flos to the water is (1: 8)-(1: 20), the reflux extraction temperature is 55-95 DEG C, the extraction times are 2-4 times, and the extraction time is 0.5-3 hours each time; filtering the extract, and combining filtrates; properly concentrating the filtrate to 1 / 5-1 / 20 of the original volume; and carrying out resin elution on the filtrate, and concentrating and drying the eluent to obtain the lonicera confusa total saponins. According to the extraction process disclosed by the invention, the use of various organic reagents is avoided, the cost and industrial energy consumption are reduced, and the purification step is reduced. The method is simple in process operation, high in raw material utilization rate and suitable for industrial production. The obtained lonicera confusa total saponin can be used for preparing solid beverages, is pleasant in fragrance and good in taste, and has the effects of protecting the liver and benefiting the gallbladder.

Description

technical field [0001] The invention belongs to the field of extraction and application of natural products, and in particular relates to a total saponin from Japonica japonica and its extraction method and its application in solid beverages. Background technique [0002] All natural medicines have important medicinal value because the active ingredients contained in them are biologically active. Mountain silver flower is the dry flower bud of the Lonicera genus Lonicera in the Lonicera family. It is a common flower medicinal material, which can be used as food or medicine. Documents at home and abroad show that the medicinal active ingredients of Lilywood are very rich, including organic acids, flavonoids, saponins, volatile oil compounds and various trace element compounds, and have many modern pharmacological effects, such as clearing heat and detoxifying, cooling Wind heat dissipation, anti-virus, anti-bacterial, liver protection and gallbladder, blood lipid lowering, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355A61P1/16A23L2/39A23L33/105A61K133/00
Inventor 杨振金显友刘泽宇魏元刚杨永安
Owner 亿利耐雀生物科技有限公司
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