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Method for effectively intervening diabetes mellitus by L-type amino acid transporter inhibitor or antagonist

A transporter and amino acid technology, which is applied in the field of L-type amino acid transporter inhibitors or antagonists to effectively intervene in diabetes, and can solve problems such as failure to improve pancreatic beta cells and restore insulin secretion function

Pending Publication Date: 2022-04-12
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most diabetes treatment drugs reduce blood sugar by inhibiting glucose absorption, increasing muscle uptake and metabolism of glucose, inhibiting glycogen production and output (i.e. symptomatic therapy), and improving insulin sensitivity of peripheral tissues to relieve symptoms. There is no treatment to increase the number of pancreatic beta cells and restore insulin secretion function

Method used

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  • Method for effectively intervening diabetes mellitus by L-type amino acid transporter inhibitor or antagonist
  • Method for effectively intervening diabetes mellitus by L-type amino acid transporter inhibitor or antagonist
  • Method for effectively intervening diabetes mellitus by L-type amino acid transporter inhibitor or antagonist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0148] Example 1 Effect of Adding Different Kinds of Essential Amino Acids on Low Protein Grain Intervention Fasting Blood Sugar

[0149] At the end of each nutritional intervention course, the changes in the fasting blood glucose of the mice after 5 consecutive weeks of dietary intervention were detected, and it was found that the blood glucose of the mice increased significantly after the STZ model was successfully established. After five weeks of intervention with low-protein food, Compared with the control group, the blood glucose of the mice in the second group decreased significantly, and the fasting blood glucose was close to normal blood glucose. When 8 different essential amino acids were added to the low-protein grain, it was found that the blood glucose of the two groups of mice added with methionine or leucine gradually returned to the same high fasting blood glucose as that of the control mice, and the addition of other amino acids did not It will not affect the e...

Embodiment 2

[0150] Example 2 Deficiency of methionine and leucine can effectively reduce fasting blood sugar in diabetic mice

[0151] Next, mouse diets lacking methionine, leucine, and methionine and leucine pairs were designed for experiments. At the end of each nutritional intervention course, the changes in fasting blood glucose of mice after 6 consecutive weeks of dietary intervention were detected. It was found that after the successful establishment of the STZ model, the blood glucose of the mice was significantly higher than that of the wild-type mice (the first group). After continuous intervention for 6 weeks, no matter the intermittent feeding of methionine deficiency, leucine deficiency or simultaneous methionine and leucine feed can effectively reduce the fasting blood glucose of mice after STZ modeling ( figure 2 , A, B). Therefore, reducing the content of these two essential amino acids, methionine or leucine, can indeed regulate fasting blood sugar.

Embodiment 3

[0152] Example 3 L-type amino acid transporter inhibitors can effectively improve fasting blood sugar

[0153] Because the content of methionine and leucine in the body is closely related to the fasting blood sugar of diabetic mice, the L-type amino acid transporter protein is mainly responsible for transporting amino acids such as methionine and leucine, so we tried an L-type amino acid The transporter inhibitor BCH was tested to see if it was also effective in lowering fasting glucose. We used intraperitoneal injection of BCH, an amino acid transporter inhibitor, in the first three days of each week to replace the effect of the lack of specific amino acids in food. After four consecutive weeks of experiments, we found that this intermittent injection of amino acid transporter inhibited The method of supplementation can effectively reduce fasting blood sugar, and this effect is even more obvious than that of the previous intermittent low-protein diet ( image 3 , A, B). The...

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Abstract

The invention relates to a method for effectively intervening diabetes mellitus by using an L-type amino acid transporter inhibitor or antagonist, and particularly provides application of the L-type amino acid transporter inhibitor or antagonist to preparation of a composition or a preparation, and the composition or the preparation is used for preventing and / or treating diabetes mellitus. And the quantity of pancreatic beta cells can be improved. It is found for the first time that the L-type amino acid transporter inhibitor or antagonist can effectively reduce fasting blood glucose of mammals and can effectively treat diabetes mellitus.

Description

technical field [0001] The invention relates to the field of biomedicine. Specifically, the present invention relates to a method for effectively intervening diabetes with an L-type amino acid transporter inhibitor or antagonist, and more particularly, the present invention relates to a method for effectively interfering with diabetes by blocking L-type amino acid transporter with an inhibitor or an antagonist. Background technique [0002] Diabetes mellitus is a complex metabolic disease characterized by high blood sugar, which is a chronic syndrome caused by the inability of the body to secrete or utilize insulin. Dietary patterns and dietary composition are considered to be one of the most important factors affecting the development of chronic diseases. At the same time, dietary restriction is an extremely effective dietary pattern for the treatment of many metabolic diseases such as diabetes, obesity, tumors, and neovascular diseases. [0003] Current diabetes treatmen...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P3/10C12Q1/02G01N33/68
CPCC12Q1/02A61P3/10A61K45/00G01N33/68
Inventor 陈雁韦思颖王滔
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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