Tissue engineering stem cell graft with suspended albumen glue scaffold

Abstract

The invention discloses a tissue engineering stem cell graft with a suspended albumen glue scaffold, and belongs to the technical field of medical biology, the tissue engineering stem cell graft comprises a catheter and an albumen glue scaffold C. The albumen glue scaffold C is provided with a plurality of suspension fibers A and suspension fibers B connected with the inner wall of the catheter along the length direction of fibers, and the albumen glue scaffold C is suspended inside the catheter through the suspension fibers C; the albumen glue support C comprises an albumen glue support A and an albumen glue support B, and the suspension fiber C comprises a suspension fiber A connected to the albumen glue support A and a suspension fiber B connected to the albumen glue support B. The mesenchymal stem cells and the Schwann cells are rich in source, convenient to obtain, easy to separate and purify, homologous cell sources are adopted, immunological rejection is avoided, and the mesenchymal stem cells and the Schwann cells are more suitable for serving as good seed cells to be used for constructing tissue-engineered stem cells; the perianal fistula repairing device is particularly used for repairing perianal fistula patients with large sizes and patients with easy relapse.

Description

technical field [0001] The invention relates to a stem cell graft, in particular to a tissue engineering stem cell graft with a suspended protein glue support, which belongs to the technical field of medical biology. Background technique [0002] Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract of unknown etiology. Due to its unknown etiology, its incidence is increasing and it also imposes a huge burden on the medical system. CD is characterized anywhere along the gastrointestinal wall Both have persistent transmural ulcerative inflammation and worsening that necessitate chronic immunosuppression and surgery to manage disease symptoms, neither of which is curative; treatment with available biologics and surgery is well known difficulties, these patients have increased cost of living and reduced quality of life due to pain, persistent drainage, recurrent perianal sepsis, and continued need to access medical care; unfortunately, 37% of PFCD pati...

AI Technical Summary

Problems solved by technology

[0002] Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract of unknown etiology. Due to its unknown etiology, its incidence is increasing and it also imposes a huge burden on the medical system. CD is characterized anywhere along the gastrointestinal wall Both have persistent transmural ulcerative inflammation and worsening that necessitate chronic immunosuppression and surgery to manage disease symptoms, neither of which is curative; treatment with available biologics and surgery is well known difficulties, these patients have increased cost of living and reduced quality of life due to pain, persistent drainage, recurrent perianal sepsis, and continued need to access medical care; unfortunately, 37% of PFCD patients have refractory disease, Current ineffective treatment modalities lead to incontinence, unemployment, increased risk of biological infection, increased incontinence due to surgical intervention, and seriously affect the quality of life of thousands of patients; in recent years, organizations based on the principles and technologies of life science and engineering have developed The engineering is to act on the patient site of Crohn's disease perianal fistula in the suspended wire scaffold to achieve slow release and complete healing of the final perianal fistula

[0003] Defects and deficiencies of the prior art: (1) At present, there is no good curative effect for this condition; (2) Crohn's disease can easily lead to recurrence or aggravation of the disease after treatment

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