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Renal clear cell carcinoma biomarker and application thereof

A technology of clear cell renal cell carcinoma and gene markers, which is applied in the field of genetic detection of clear cell renal cell carcinoma, can solve problems such as the failure to form a prediction model, and achieve the effect of avoiding excessive medical treatment and inhibiting the proliferation and migration of clear cell renal cell carcinoma

Pending Publication Date: 2022-04-15
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Memorial Sloan Kettering Cancer Center (MSKCC) model is the first prediction model established in the era of immunotherapy, but a set of prediction models based on gene expression levels has not yet been formed. A more direct and intimate link between tumor responsiveness to therapy

Method used

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  • Renal clear cell carcinoma biomarker and application thereof
  • Renal clear cell carcinoma biomarker and application thereof
  • Renal clear cell carcinoma biomarker and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Example 1: Screening of gene signatures associated with clear cell renal cell carcinoma

[0046] First, the transcriptome sequencing data and clinical information of 30 cancers were obtained from the TCGA database, and the gene expression data of the human rhomboid protein family and patient survival data were extracted for single-factor COX analysis to obtain the hazard ratio (HR) related to gene expression. , the analysis results were tested using log-rank test for significance, figure 1 It is a graphical COX analysis result. exist figure 1 The bar chart on the right counts the proportion of each gene in adverse risk in 30 cancers, among which RHBDF2 has a higher risk. Overall, the cancers in which patient survival was significantly influenced by gene expression across the family were adrenocortical carcinoma (ACC), low-grade brain glioma (LGG), and kidney renal clear cell carcinoma. carcinoma, KIRC). figure 2 The results of the risk analysis for the three cancer...

Embodiment 2

[0048] Example 2: Relationship between patients with high RHBDF2 expression and clinical features of renal clear cell carcinoma

[0049] The RHBDF2 expression data of patients with clear cell renal cell carcinoma downloaded from the TCGA database were matched and compared with the clinical data, grouped according to the expression level of RHBDF2, and divided into RHBDF2 high expression group and RHBDF2 low expression group with the median of RHBDF2 expression as the boundary, The age level, tumor stage, pathological grade, metastasis and lymphatic metastasis of patients in each group were counted. As shown in Table 1, the average age at diagnosis of clear cell renal cell carcinoma is 60 years old, and the age at diagnosis of patients with high RHBDF2 expression is mostly lower than the average age of 60 years. Compared with the group with low RHBDF2 expression, there are more Patients with high-grade tumors and advanced disease also had more metastases. The chi-square test w...

Embodiment 3

[0054] Example 3: The expression of RHBDF2 is positively correlated with the immune infiltration level of renal clear cell carcinoma

[0055] A high level of immune infiltration is one of the characteristics of clear cell renal cell carcinoma. In renal cancer, the state of immune cell infiltration has a great impact on the treatment response and disease progression of patients. Highly immunosuppressive immune cell infiltration is not conducive to the improvement of patients' disease. Use the R package "ESTIMATE" to calculate the immune score of the patient sequencing data in the TCGA database and GSE68417, and then calculate the Pearson correlation coefficient between the expression of RHBDF2 and the immune score of each patient. The results are as follows Figure 6 A, B, RHBDF2 levels are positively correlated with immune scores.

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Abstract

The invention provides a renal clear cell carcinoma biomarker and application thereof, and provides reference data for diagnosis and immunotherapy regimen of renal clear cell carcinoma. The gene marker RHBDF2 provided by the invention has specificity in the renal clear cell carcinoma and can be used as a novel marker for evaluating the renal clear cell carcinoma.

Description

technical field [0001] The invention relates to the field of gene detection of renal clear cell carcinoma, and relates to a biological marker of renal clear cell carcinoma and its application. Background technique [0002] Renal cancer is one of the most common types of cancer in the world, accounting for about 2% of adult malignant tumors. Among them, renal clear cell carcinoma is a renal cancer with a high incidence and metastasis rate, accounting for 78% of the total renal cancer. In China, about 66,800 new cases of kidney cancer are diagnosed each year, and about 23,400 people die of kidney cancer. Clear cell renal cell carcinoma has no obvious symptoms in the early stage of the disease, and about 30% of the patients are already in the advanced stage when they are diagnosed. Treatment for clear cell renal cell carcinoma includes surgical resection, radiotherapy and chemotherapy, and targeted therapy. However, early clear cell renal cell carcinoma still has a recurrence ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11
Inventor 李鲁远王蕾张智松王滟宋圆圆
Owner NANKAI UNIV
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