Microneedle with fat-soluble active matter loaded on surface and preparation method of microneedle

Abstract

The invention relates to the field of microneedles, and discloses a microneedle with a fat-soluble active matter loaded on the surface and a preparation method thereof.The microneedle is prepared by curing, dehydrating and forming a water-soluble matter of a microneedle matrix on a female template, and the preparation method comprises the steps that a female template solution is poured into a female template forming container, and demolding is conducted after curing to obtain a female template; injecting a fat-soluble active matter solution into the microneedle forming holes of the female template, removing bubbles, then dipping, and pouring out redundant active matters after dipping to obtain a pre-coated active matter female template; the water-soluble substance of the microneedle matrix is poured into the pre-coated active matter female template, bubbles in the water-soluble substance are emptied, and after curing, demolding is conducted to prepare the microneedle with the fat-soluble active matter loaded on the surface; according to the invention, the problem that a water-soluble microneedle matrix is difficult to load fat-soluble active matters is solved, and the quantitative loading effect of the microneedle is achieved by designing a female template; and the process of preparing the microneedle and the process of loading the fat-soluble active matter on the microneedle are simultaneously carried out, so that the process flow is simplified, and the yield of the microneedle is remarkably increased.

Description

technical field [0001] The invention relates to the field of microneedles, in particular to a microneedle loaded with fat-soluble active substances on the surface and a preparation method thereof. Background technique [0002] Microneedle is a painless drug delivery device, which is divided into pure matrix type microneedle and active material loading microneedle; microneedle is divided into soluble, partially soluble and insoluble type according to the characteristics of the matrix, and the active material can be coated Or it can be mixed with the matrix to achieve the purpose of loading; by piercing several tiny channels on the skin surface to promote the release of drugs or other active substances, it has great prospects for the development of medical aesthetics / medicine; the microneedle structure has a high aspect ratio, The characteristics of fine structure and low mechanical strength usually lead to problems such as difficult loading of active substances, uneven coatin...

AI Technical Summary

Problems solved by technology

[0005] In the prior art, the premixing technology of the active substance and the matrix requires good compatibility between the active substance and the microneedle, and the method of dipping and coating the needle tip often causes excessive coating to the inner side of the backing or even the whole body due to capillary force and surface tension. Submerged; Spraying the needle tip method is difficult to control the strength of the spray gun, and the problem of needle tip damage is prone to occur. Therefore, it is necessary to provide a microneedle with a fat-soluble active substance on the surface and a preparation method thereof to solve this problem.

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