Nanometer fat functionalized injectable super-lubricating microsphere as well as preparation method and application thereof
A functional and super-lubricating technology, applied in non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problem of high lubricating performance, easy increase of friction coefficient, injectable nano-fat Short maintenance time and other issues to achieve the effects of enhancing lubrication, inhibiting the occurrence of osteoarthritis, improving loading efficiency and inducing stem cell secretion
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[0041] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be described in detail below in conjunction with the examples. It must be pointed out that the following examples are only used to explain and illustrate the present invention, and are not intended to limit the present invention . Some non-essential improvements and adjustments made by those skilled in the art based on the above content of the invention still belong to the protection scope of the present invention.
[0042] Experimental method example 1
[0043] 1. Experimental materials
[0044] 1. Main drugs and reagents
[0045] Formylated polylactic-co-glycolic acid (PLGA-CHO, M w =10KDa) was purchased from Guangzhou Carbon Water Technology Co., Ltd. (China); TNF-α (tumor necrosis factor) was purchased from Peprotech (USA); bovine serum albumin (BSA)-FITC was purchased from Beijing Solarbio Technology Co., Ltd. (China); Barbital sodium...
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