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Nanometer fat functionalized injectable super-lubricating microsphere as well as preparation method and application thereof

A functional and super-lubricating technology, applied in non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problem of high lubricating performance, easy increase of friction coefficient, injectable nano-fat Short maintenance time and other issues to achieve the effects of enhancing lubrication, inhibiting the occurrence of osteoarthritis, improving loading efficiency and inducing stem cell secretion

Active Publication Date: 2022-04-29
SUZHOU MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The technical purpose of the present invention is to: overcome the problem that the lubricating effect of the injectable nano-fat in the prior art is short, the friction coefficient is easy to increase, and it is difficult to maintain high lubricating performance stably for a long time

Method used

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  • Nanometer fat functionalized injectable super-lubricating microsphere as well as preparation method and application thereof
  • Nanometer fat functionalized injectable super-lubricating microsphere as well as preparation method and application thereof
  • Nanometer fat functionalized injectable super-lubricating microsphere as well as preparation method and application thereof

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Embodiment Construction

[0041] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be described in detail below in conjunction with the examples. It must be pointed out that the following examples are only used to explain and illustrate the present invention, and are not intended to limit the present invention . Some non-essential improvements and adjustments made by those skilled in the art based on the above content of the invention still belong to the protection scope of the present invention.

[0042] Experimental method example 1

[0043] 1. Experimental materials

[0044] 1. Main drugs and reagents

[0045] Formylated polylactic-co-glycolic acid (PLGA-CHO, M w =10KDa) was purchased from Guangzhou Carbon Water Technology Co., Ltd. (China); TNF-α (tumor necrosis factor) was purchased from Peprotech (USA); bovine serum albumin (BSA)-FITC was purchased from Beijing Solarbio Technology Co., Ltd. (China); Barbital sodium...

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Abstract

The invention provides a nano fat functionalized injectable super-lubricating microsphere as well as a preparation method and application of the nano fat functionalized injectable super-lubricating microsphere. The preparation method comprises the following steps: firstly, preparing PLGA porous microspheres by utilizing a microfluidic technology, and then fixing nano fat rich in grease, stem cells and growth factors in the microspheres through a Schiff base condensation reaction, non-covalent interaction and a three-dimensional carrier physical network structure, so as to obtain the nano fat functionalized injectable super-lubricating microspheres. After the microspheres are injected through an articular cavity, cartilage surface adhesion targeted colonization is achieved, and friction experiments verify that the microspheres have the super-lubrication characteristic. In addition, osteophyte formation is remarkably reduced in vivo, the behavioral performance of rats is improved, and the process of osteoarthritis is inhibited. The invention provides a multifunctional platform with great potential for minimally invasive treatment of osteoarthritis and even alleviation of disease progress.

Description

technical field [0001] The invention belongs to the technical field of nano-fat functionalized products and preparation, and in particular relates to a nano-fat functionalized injectable super-lubricating microsphere and its preparation method and application. Background technique [0002] Tonnard et al. reported for the first time in 2013 the preparation of a fine emulsion with the advantages of liquid and homogeneous liquid by mechanically emulsifying micro fat, which is called "nano fat". Nanofat is an injectable viscous extract rich in lipids, growth factors and stem cells, which has been successfully used in the fields of scar repair, ischemic angiogenesis of limbs and cartilage defect repair. [0003] Nanofat is an ideal stent-free graft due to its multiple components and multifunctional properties (angiogenic, anti-fibrotic, analgesic, and anti-inflammatory). However, existing studies have shown that nanofat after injection has problems of low biological activity and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K35/35A61K47/34A61P19/02A61P19/08A61P29/00
CPCA61K9/1647A61K9/0019A61K35/35A61P19/08A61P19/02A61P29/00
Inventor 杨兴韩泽宇韩启斌崔文国郝跃峰
Owner SUZHOU MUNICIPAL HOSPITAL
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