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Method for detecting concentration of glucose in hemodialysis fluid

A technology of glucose concentration and hemodialysis, which is applied in the field of detection of glucose concentration in hemodialysis fluid, can solve the problems of unstable zero point fluctuation, very high precision and stability requirements, and low accuracy of detection results, so as to ensure accuracy , Shorten the detection time, the effect of simple pre-processing process

Pending Publication Date: 2022-05-10
山东威高肾科医疗器械有限公司
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  • Application Information

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Problems solved by technology

However, the glucose content of most of the existing dialysates is 1g / L, and its optical rotation is about 0.05. The standard for the unstable zero point fluctuation of the polarimeter identified in the "Chinese Pharmacopoeia" General Rule 0621 "Optical Rotation Measurement Method" is that the difference exceeds ± The values ​​of 0.01 and 0.05 have very high requirements on the accuracy and stability of the instrument, and the accuracy of the test results is not strong

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  • Method for detecting concentration of glucose in hemodialysis fluid
  • Method for detecting concentration of glucose in hemodialysis fluid
  • Method for detecting concentration of glucose in hemodialysis fluid

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Embodiment 1

[0033] A method for detecting glucose concentration in hemodialysate, specifically comprising the following steps:

[0034] (1) Preparation of the test solution: take the hemodialysis concentrate A and B liquid to prepare the test solution according to the instructions for use, and set aside;

[0035] Glucose reference substance solution preparation (containing glucose C 6 h 12 o 6 ·H 2 (2 1.1g / L): Accurately weigh 20 mg of anhydrous glucose reference substance processed according to the instruction manual in a 20ml volumetric flask, add water to dissolve and set the volume to the scale, mix well and get ready for use;

[0036] (2) System suitability test methods and requirements:

[0037] Precisely measure 20 μl of the glucose reference solution, inject it into the liquid chromatograph, measure it continuously for 5 times, and record the chromatogram; calculate the RSD of the main peak area of ​​glucose, the number of theoretical plates and the degree of separation, and t...

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Abstract

The invention discloses a method for detecting the concentration of glucose in a hemodialysis solution, which specifically comprises the following steps: (1) preparation of a test solution: preparing the hemodialysis solution into the test solution for later use; preparing a glucose reference solution for later use; and (2) taking the test solution and the glucose reference substance solution, injecting the test solution and the glucose reference substance solution into a college liquid chromatograph for determination, recording a chromatogram, and calculating by peak area according to an external standard method to obtain the glucose concentration. The detection method disclosed by the invention is simple and convenient to operate, meets the requirements of qualitative and quantitative determination by utilizing the high performance liquid chromatography, has good reproducibility, high accuracy and good linearity, and is beneficial to control of the content of glucose in the hemodialysis fluid.

Description

technical field [0001] The invention belongs to the technical field of medical detection, in particular to a method for detecting glucose concentration in hemodialysate. Background technique [0002] Hemodialysis is one of the renal replacement therapies for patients with acute and chronic renal failure. During the hemodialysis process, as toxins and water are removed, the glucose in the patient's body is also removed. Therefore, hypoglycemia often occurs in patients in the middle and late stages of hemodialysis, but, especially in end-stage diabetic nephropathy patients, Due to the changes in insulin metabolism and sensitivity, as well as the impact of the body's glucose entering the dialysate during hemodialysis, hypoglycemia is more likely to occur in patients with normal dialysis than ordinary dialysis patients. blood sugar and reduce the incidence of hypoglycemia. [0003] In the prior art, for sugar-containing dialysate, YY 0598-2015 "Hemodialysis and Related Treatme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/027
Inventor 张燕玉柯军叶晓燕杜武华李鹏娥刘新玲徐凤仪丁四海王雪燕
Owner 山东威高肾科医疗器械有限公司
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