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Sodium usnic acid solution and preparation method thereof

A technology of sodium usnic acid and solution, applied in the field of medicine, can solve the problems of low component content of usnic acid sodium, unstable system, etc., and achieve the effects of less variety and simple process

Active Publication Date: 2022-05-13
BEIJING CENT BIOLOGY +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of usnic acid sodium solution and preparation method thereof, solve the low usnic acid sodium component content in conventional usnic acid sodium aqueous solution, And the problem of system instability

Method used

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  • Sodium usnic acid solution and preparation method thereof
  • Sodium usnic acid solution and preparation method thereof
  • Sodium usnic acid solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Weigh multiple parts of 1g of usnea sodium, add 30g of Tween 80, PEG200, glacial acetic acid, OP-10, ethanol, PEG60-hydrogenated castor oil or PEG40-hydrogenated castor oil respectively, and then dilute to volume with purified water After reaching 100mL, magnetically stir for 60min.

[0040] Such as Figure 2-8 As shown, the samples prepared by adding Tween 80, PEG200, glacial acetic acid, OP-10, and ethanol could not achieve clarification, while the samples prepared by adding PEG60-hydrogenated castor oil and PEG40-hydrogenated castor oil had better clarity.

Embodiment 2

[0042] Weigh 2 parts of 1g of sodium usnicate, add 30g of PEG60-hydrogenated castor oil or 30g or PEG40-hydrogenated castor oil respectively, and then dilute to 100mL with purified water and stir magnetically for 60min.

[0043] The prepared samples were placed in a refrigerator at 4°C for continuous observation.

[0044] Such as Figure 9-10 As shown, the sample that added PEG40-hydrogenated castor oil had precipitation on the second day, and the sample that added PEG60-hydrogenated castor oil had a small amount of precipitation on the 12th day.

Embodiment 3

[0046] Weigh 3 parts of 1g sodium usnicate, add 30g of PEG60-hydrogenated castor oil to each part, then add 20g of propylene glycol, glycerol or PEG200, respectively, use purified water to make up to 100mL, and stir magnetically for 60min.

[0047] The prepared samples were placed in a refrigerator at 4°C for continuous observation.

[0048] Such as Figure 11-13 As shown, the sample added with PEG200 began to appear a small amount of precipitation on the 15th day, while the sample added with propylene glycol or glycerin did not precipitate at 60 days.

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Abstract

The invention relates to a sodium usnic acid solution and a preparation method thereof. The preparation method comprises the following steps: (1) uniformly mixing sodium usnic acid, PEG60-hydrogenated castor oil, glycerol and / or propylene glycol; (2) adding purified water to a constant volume; and (3) stirring until the materials are dissolved. According to the sodium usnic acid solution and the preparation method thereof provided by the invention, the problem of low sodium usnic acid content caused by low solubility of sodium usnic acid in a conventional sodium usnic acid aqueous solution is solved, and the problems of more auxiliary materials, complex preparation process, unclarified suspension and the like in the preparation of the sodium usnic acid solution in the prior art are also solved; the preparation method of the sodium usnic acid solution provided by the invention is simple in process, and few types of auxiliary materials are used. The prepared solution is clear and transparent, and the precipitation phenomenon does not occur after long-time low-temperature storage.

Description

technical field [0001] The invention mainly relates to the technical field of medicine, in particular to a sodium usnicate solution and a preparation method thereof. Background technique: [0002] Usnic acid (Usnic Acid, UA), also known as lichenic acid, is derived from the dried lichens of Usnea diffracta Vain. and Usnea longissima Ach. Usnic acid sodium is the sodium salt of usnic acid, and the application fields of the two are basically the same. The research content at home and abroad mostly focuses on the extraction and separation, biosynthesis, and pharmacological activity of usnic acid. Usnic acid has antibacterial, anti-radiation, antiseptic and other effects. Usnic acid has been used in dietary additives, perfumes, cosmetics and other industries, and is added as a pure substance to toothpaste, mouthwash, deodorant, sunscreen and weight loss. Products etc. However, it is still in the research stage in the field of medicine, and there are only a small number of repo...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/343A61K47/10A61K47/44A61P31/04A61P39/00
CPCA61K31/343A61K9/08A61K47/44A61K47/10A61P31/04A61P39/00
Inventor 李福元温天乙王秀敏江厚生
Owner BEIJING CENT BIOLOGY
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