Anti-rhinitis traditional Chinese medicine composition with analgesic effect

Abstract

The invention discloses an anti-rhinitis traditional Chinese medicine composition which comprises the following traditional Chinese medicine raw materials: scutellaria baicalensis, ligusticum wallichii, magnolia flower, radix angelicae, bamboo juice, rhizoma acori graminei, thunberg fritillary bulb, platycodon grandiflorum, poria cocos, agastache rugosus and mint, the sum of the dosage of the scutellaria baicalensis and the dosage of the ligusticum wallichii is 2-4 times of the dosage of the bamboo juice, and preferably, the sum of the dosage of the scutellaria baicalensis and the dosage of the ligusticum wallichii is 3 times of the dosage of the bamboo juice. According to the anti-rhinitis traditional Chinese medicine composition provided by the invention, the compatibility design of a formula is reasonable, the monarch, minister, assistant and guide medication is scientific, the treatment purpose is single and clear, and the bamboo juice is innovatively used as a minister drug to be combined with a monarch drug containing a baical skullcap root-szechuan lovage rhizome pair to achieve the accidental treatment effect of cooperating with the monarch drug to synergistically relieve pain; moreover, the composition provided by the invention can also effectively treat allergic rhinitis, alleviates the irritation of the medicine to rhinitis patients, and has great clinical application value and market development potential.

Description

technical field [0001] The technical field of the traditional Chinese medicine preparation of the present invention specifically relates to an anti-rhinitis traditional Chinese medicine composition with analgesic effect, especially for the irritation in the nasal cavity of patients with rhinitis due to wind-heat, and has a strong analgesic effect. Background technique [0002] Rhinitis is an inflammation of the nasal mucosa, caused by bacteria, viruses, allergens, etc. In recent years, the incidence of rhinitis in China has been as high as 37%, and the number of patients is gradually increasing by 3% every year. The trend of younger rhinitis patients is also becoming more and more obvious. Teenagers and children with rhinitis account for 2 / 3 of the rhinitis population. Patients with rhinitis can be classified according to the type of disease, and can be divided into patients with allergic rhinitis (AR, also known as "allergic rhinitis") and patients with non-allergic rhiniti...

AI Technical Summary

Problems solved by technology

[0004] Existing treatments for allergic rhinitis (AR) include surgical treatment, desensitization treatment, and drug therapy. Surgical treatment is expensive, ineffective, and has many sequelae, and may cause dry atrophic rhinitis

Desensitization therapy can cure allergic rhinitis, but it requires that the patient has simple allergic rhinitis and there is a corresponding allergen vaccine. Specific patients need to find symptomatic allergens for immunotherapy, which is like finding a needle in a haystack; ②The same person is often allergic to multiple substances, so it is more difficult to find multiple symptomatic allergens; ③Not all allergens can be desensitized, such as dust mites , Ultraviolet allergy, that is, substances that cannot be desensitized; ④Desensitization therapy itself has problems such as long cycle, slow onset, large side effects, and easy to cause systemic or local adverse reactions, so it is generally difficult for patients to persist

However, its disadvantages are: it is easy to relapse and difficult to cure after stopping the drug, the course of allergic reaction cannot be changed, and individualized treatment for a single symptom cannot be realized, and the treatment cycle is too long; a large proportion of AR patients are not satisfied with the drug treatment results (Jia Yifan, Chen Sheng, Wen Zhihong, Xie Qi, Zhao Jiping. Effect of herbal-partitioned moxibustion combined with raynocort on clinical symptoms and sleep quality of patients with persistent moderate to severe allergic rhinitis[J]. Acupuncture Research, 2020, 45(1):46-50.)

However, its shortcoming is that it does not take into account the irritating reaction to the nasal cavity after taking the medicine in patients with rhinitis, and the hidden dangers of adverse reactions to the digestive system and other organs caused by oral administration of cocklebur.

The traditional Chinese medicine composition can be used to treat allergic rhinitis and mixed rhinitis with turbinate hypertrophy, but the disadvantage of the patented technical solution is that it does not take into account the irritant reaction to the nasal cavity after taking the medicine for rhinitis patients, and the analgesic effect is weak

[0010] The AR treatment drugs involved in the aforementioned literatures have common shortcomings: ①When treating allergic rhinitis, the impact of the irritation of the drug on the patient is not considered, especially the pain and discomfort in the patient's nasal cavity; ②Some drugs There are obvious adverse reactions, such as damage to organs such as the digestive system, nasal mucosal ulcers, angioedema, etc.

As a result, many rhinitis patients refuse to eat because of pain, which affects nutritional intake and is not conducive to the recovery of patients (Wang Ying, Analysis of the effect of swallowing surface electromyography on the pain degree of patients with perennial allergic rhinitis[J]. Journal of North Sichuan Medical College, 2017,32(1):109-111.)

[0012] Regrettably, in traditional Chinese medicine treatment, the prescriptions used are all focused on expelling wind and clearing the nasal orifices. It is difficult to treat nasal pain while treating wind-heat rhinitis

[0013] For example, the mai rhinitis spray prepared by Li Yingchun and others through improved technology is composed of ephedra, magnolia, asarum, cork, borneol, etc. It can treat acute rhinitis, chronic rhinitis, allergic rhinitis and sinusitis and other symptoms, with remarkable curative effect But the weak point of this technical scheme is: although Herba Asarum can be used for analgesic, antitussive, toxic side effect is obvious, must strictly control dosage (Li Yingchun. The preclinical research [D] of Ma Yi rhinitis spray. Guangdong Pharmacy College ,2011.)

However, the disadvantage of this formula is that the cocklebur is used in the formula, and there are hidden dangers of adverse reactions that can easily cause organ damage when taken orally.

However, the disadvantage of this prescription is that: cocklebur and asarum are used in a large amount in the prescription, there are hidden dangers of toxic and side effects, and the safety of the medicine must be strictly controlled

[0017] In summary, among the existing anti-rhinitis traditional Chinese medicine compositions, bamboo leek is mostly used for clearing away heat and resolving phlegm, and there is no literature report that it can be used as a ministerial drug in combination with Scutellaria baicalensis and Chuanxiong to treat nasal pain associated with allergic rhinitis

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