Triazine compound and application thereof in preparation of antiviral drugs

A compound and drug technology, applied in the field of triazine compounds and their use in the preparation of antiviral drugs, can solve the problems of difficulty in generating effective immunity, low immunization rate, shortening and the like, and achieve a reduction in single administration Dosage, increase blood concentration, and the effect of good therapeutic effect
CN114507221AActive Publication Date: 2022-05-17YAOKANG ZHONGTUO (JIANGSU) PHARMA TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YAOKANG ZHONGTUO (JIANGSU) PHARMA TECH CO LTD
Publication Date
2022-05-17

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Abstract

The invention relates to a triazine compound with a structure represented by a formula A, or a stereoisomer, a prodrug, an active metabolite or a pharmaceutically acceptable salt, a solvate or a crystal form thereof, a pharmaceutical composition of the triazine compound, the stereoisomer, the prodrug, the active metabolite or the pharmaceutically acceptable salt, the solvate or the crystal form, and a use method of the triazine compound. In addition, the invention also relates to a method for preparing a 3C-like cysteine protease inhibitor or a medicine for treating and / or preventing virus infectious diseases. In particular, the present invention relates to the use for treating viral infectious diseases such as Middle East Syndrome Related Coronavirus (MERS-CoV), Severe Acute Respiratory Syndrome Related Coronavirus (SARS-CoV), Influenza A virus, Influenza B virus, Novel Coronavirus Pneumonia (COVID-19) and the like.
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Description

technical field

[0001] The present invention provides a triazine compound or its stereoisomer, prodrug, active metabolite or pharmaceutically acceptable salt, solvate or crystalline form, its preparation method, a pharmaceutical composition containing it, and the use of the combination The use of substances for the prevention or treatment of viral infectious diseases. Background technique

[0002] Coronavirus (coronavirus) belongs to the genus Coronaviridae Coronaviridae in terms of systematic classification. Mature coronaviruses are corona-shaped or crown-shaped under the electron microscope, so they are named coronaviruses, which can easily cause central nervous system diseases, common colds, and lower respiratory tract infections. and diarrhea. In 2003, SARS-CoV-1 was the first coronavirus to spread in humans, causing more than 900 deaths (case fatality rate 10-15%), and more than 8,000 people were infected. In 2012, Middle East Respiratory Syndrome Coronavirus (MERS-Co...

Claims

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