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Medicine for preventing and treating metabolic syndrome induced by saturated fatty acid

A fatty acid and drug technology, applied in metabolic diseases, drug combinations, active ingredients of anhydride/acid/halide, etc.

Pending Publication Date: 2022-05-27
王璐 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But so far, there is no report about the effect of 2-bromohexadecanoic acid on the endoplasmic reticulum stress and its pathological damage induced by saturated fatty acids

Method used

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  • Medicine for preventing and treating metabolic syndrome induced by saturated fatty acid
  • Medicine for preventing and treating metabolic syndrome induced by saturated fatty acid
  • Medicine for preventing and treating metabolic syndrome induced by saturated fatty acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0042] The experimental animals and material sources used in the following experiments are as follows:

[0043] The C2C12 cell line was purchased from the National Biomedical Experimental Cell Resource Bank.

[0044] Test drug: 2-bromohexadecanoic acid, purchased from Sigma-Aldrich (Shanghai) Trading Co., Ltd., purity: 97%, item number 238422.

[0045] Other material sources: fetal bovine serum, high glucose DMEM medium, horse serum, ATF4, CHOP, TNF-alpha, IL-6, Caspase 3 spliceosome and phosphorylated AKT antibody were purchased from Cell Signaling Technology;

[0046] Main equipment: Bole electrophoresis apparatus, electrophoresis tank.

[0047] Experiment 1: The effect of 2-bromohexadecanoic acid on saturated fatty acid-induced endoplasmic reticulum stress

[0048]1. Experimental purpose:

[0049] To investigate the effect of 2-bromohexadecanoic acid on saturated fatty acid-induced endoplasmic reticulum stress.

[0050] 2. Experimental method:

[0051] The myoblast cel...

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Abstract

The invention provides a medicine for preventing and treating metabolic syndrome induced by saturated fatty acid. Experiments prove that the 2-bromohexadecanoic acid can inhibit endoplasmic reticulum stress, inflammatory response, apoptosis and insulin resistance caused by high saturated fatty acid diet, and can be used for preparing medicines for preventing and resisting metabolic syndromes caused by obesity or high fat diet.

Description

Technical field: [0001] The present invention relates to a medicine for preventing and treating metabolic syndrome induced by saturated fatty acid. Background technique: [0002] Hyperlipidemia caused by excessive intake of fat causes pathological changes such as fatty liver, hyperglycemia, hyperinsulinemia, hypertension, impaired glucose tolerance, insulin resistance and obesity, collectively referred to as metabolic syndrome. Studies have shown that the increased concentration of saturated fatty acids in the blood is the main culprit in causing metabolic syndrome. [0003] The endoplasmic reticulum is an important intracellular organelle that can participate in the folding and modification of proteins. Saturated fatty acids can induce endoplasmic reticulum stress (ie, normal endoplasmic reticulum dysfunction) in tissue cells, causing pathological damage such as chronic tissue inflammation, insulin resistance, and cell apoptosis. Therefore, endoplasmic reticulum stress pl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/20A61P3/00A61P3/04A61P3/06A61P29/00A61P5/50A61P21/00
CPCA61K31/20A61P3/00A61P3/04A61P3/06A61P29/00A61P5/50A61P21/00
Inventor 王璐张鹏
Owner 王璐
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