Preparation method of swimming bladder-based myocardial patch

A swim bladder and myocardium technology is applied in the field of preparation of swim bladder-based myocardial patches, and can solve the problems of secondary surgery trauma of patients and the like

Active Publication Date: 2022-06-03
ZHEJIANG UNIV HANGZHOU GLOBAL SCI & TECH INNOVATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a method for preparing a swim bl

Method used

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  • Preparation method of swimming bladder-based myocardial patch
  • Preparation method of swimming bladder-based myocardial patch
  • Preparation method of swimming bladder-based myocardial patch

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Embodiment Construction

[0040] The present invention provides a method for preparing a swim bladder-based myocardial patch. In order to make the purpose, technical solution and effect of the present invention clearer and clearer, the present invention is further described below in detail. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

[0041] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terms used herein in the description of the present invention are for the purpose of describing specific embodiments only, and are not intended to limit the present invention.

[0042] like figure 1 As shown, in an implementation of the present invention, the preparation method of the swim bladder-based myocardial patch specifically includes:

[0043] S100: afte...

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Abstract

The invention discloses a preparation method of a swim bladder-based myocardial patch. The preparation method comprises the following steps: (1) depositing metal nanoparticles on a swim bladder in situ to obtain a modified conductive swim bladder base material; and (2) packaging one surface of the conductive swimming bladder base material and hydrogel prepared from fish gelatin collagen, and coating and packaging the edge contact position of the conductive swimming bladder base material and the hydrogel with fish gelatin-based biological glue to obtain the swimming bladder-based myocardial patch. According to the swim bladder-based myocardial patch provided by the invention, along with relaxation and contraction of the heart, piezoelectric polarization can be generated in the swim bladder to generate a piezoelectric effect, so that the conductive swim bladder base material and the attached myocardial damaged part can be subjected to electrical stimulation therapy in one-time beating of the heart, and repair of the damaged myocardial part is promoted.

Description

technical field [0001] The invention relates to the technical field of myocardial repair, in particular to a preparation method of a swim bladder-based myocardial patch. Background technique [0002] All current treatments for heart disease are designed to lessen the damage done to the heart, there is no way to repair damage that has already been done, because once the muscle on the heart dies, it does not regrow, and the heart patch can repair the damage heart muscle. The cardiac patch can provide mechanical support and restore electromechanical coupling at the site of myocardial infarction, reduce myocardial remodeling, and maintain normal cardiac function. [0003] In order to carry out heart repair, many existing methods require open surgery, and further treatment is required for two or even multiple times, which is likely to cause secondary damage to the patient. Although the reported myocardial patch can repair the damaged myocardial area, because it is in the heart,...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/04A61L27/24A61L27/50
CPCA61L27/3604A61L27/3641A61L27/047A61L27/24A61L27/50A61L2430/20A61L2400/12A61L27/367
Inventor 王玮戴剑
Owner ZHEJIANG UNIV HANGZHOU GLOBAL SCI & TECH INNOVATION CENT
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