Organic solvent removing device for medicinal particles

Abstract

The invention discloses an organic solvent removal device for medicinal particles, the organic solvent removal device (10) comprises at least one flow channel (100), and the flow channel (100) for liquid to spontaneously flow under the action of gravity comprises at least one inlet and at least one outlet; adding a suspension or emulsion formed by dispersing medicinal particles containing an organic solvent in liquid into the flow channel (100) from the bottom of the inlet, and adjusting the liquid adding speed to form a liquid layer with the thickness of not more than 2mm at the bottom of the flow channel (100); and the filtered and sterilized gas is added into the flow channel (100) through the upper part of the inlet, so that the gas is in full contact with the surface of the liquid layer to take away organic solvent vapor deposited at the gas / liquid interface and discharge the organic solvent vapor from the outlet (103). According to the device, organic solvent steam deposited at the gas / liquid interface can be updated in time, and the organic solvent can be quickly removed while medicinal particles are not damaged.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical production, in particular to an organic solvent removal device for pharmaceutical particles. Background technique [0002] A large number of organic solvents are inevitably used in the pharmaceutical production process. Most of these organic solvents are harmful to the human body and need to be removed in the final product. The organic solvent in the particles can be removed by vacuum drying, freeze drying, heating, etc. However, in some cases, especially when the particles themselves are unstable and cannot withstand the above process, it is necessary to remove the organic solvent under relatively mild conditions. Solvent, liquid drying method is a suitable process. [0003] In-liquid drying method is a process of removing organic solvent in liquid. With the help of the buoyancy of water or aqueous solution (referred to as water phase, the same below), the medicinal particles containing o...

AI Technical Summary

Problems solved by technology

However, since the gas / liquid interface only exists on the surface of the water phase, the surface area of ​​the water phase is relatively limited, and the flow rate of the gas is often limited, so the transfer rate of the organic solvent in the water phase to the air is relatively slow.

[0004] For the latter, an improvement method is to introduce gas into the water phase. While increasing the gas flow rate, the gas / liquid interface can be greatly increased to speed up the diffusion and transfer of organic solvents in the water phase to the gas, but this method will A large number of bubbles are generated in the water phase. On the one hand, it may have a shearing effect on the medicinal particles and affect the stability of the medicinal particles. influences

In addition, another problem with the in-liquid drying method is that the density of organic solvent vapor is often higher than that of common gases such as air and nitrogen, which causes a large amount of organic solvent vapor to accumulate on the gas / liquid interface, hindering the mass transfer process between gas and liquid

The effect of direct introduction of fresh gas replacement is not ideal

Images