Application of pulsatilla saponin B4 in preparation of medicine or health food for preventing, relieving or treating sarcopenia

A technology of Pulsatilla saponin and health food, which is applied in the directions of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Active Publication Date: 2022-07-01
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no effective clinical treatme

Method used

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  • Application of pulsatilla saponin B4 in preparation of medicine or health food for preventing, relieving or treating sarcopenia
  • Application of pulsatilla saponin B4 in preparation of medicine or health food for preventing, relieving or treating sarcopenia
  • Application of pulsatilla saponin B4 in preparation of medicine or health food for preventing, relieving or treating sarcopenia

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0036] The preparation method of Pulsatilla saponin B4 solution is as follows: the physiological saline solution of Pulsatilla saponin B4 and PEG400 is mixed to prepare solutions with concentrations of Pulsatilla saponin B4 of 10 mg / L and 20 mg / L, respectively.

[0037] 2. Experimental grouping and experimental method

[0038] 6 male 3-month-old C57BL / 6N mice were selected as the young control group (Young), and 18 male 15-month-old mice were randomly divided into 3 groups, namely: the old control group (Old) 6 mice, which were given low-dose There were 6 rats in the drug group (Low) and 6 rats in the high-dose administration group (High).

[0039] The young control group (Young) and the old control group (Old) were given 0.3 mL of PEG400 saline solution by intraperitoneal injection, once a day for 21 consecutive days.

[0040] The low-dose administration group (Low) was given 0.3 mL of Pulsatilla saponin B4 solution with a concentration of 10 mg / L by intraperitoneal injectio...

experiment Embodiment 1

[0041] Experimental Example 1: Regarding the relationship between Pulsatilla saponin B4 and body weight.

[0042] 1. Experimental steps

[0043] Body weight is an important indicator reflecting animal growth or aging and drug toxicity. The body weight changes of mice in each group were recorded before daily administration.

[0044] 2. Experimental results

[0045] The body weight changes of each group of mice obtained in the experiment are as follows: figure 1 shown. Depend on figure 1 It can be seen that there is no statistical difference in the body weight of the mice in the young control group, the old control group, the low-dose administration group and the high-dose administration group, indicating that Pulsatilla saponin B4 is safe and non-toxic and will not cause weight changes.

experiment Embodiment 2

[0046] Experimental Example 2: Regarding the relationship between Pulsatilla saponin B4 and muscle strength.

[0047] 1. Experimental steps

[0048]After 30 minutes of administration every other day, the grasping force of the mice in each group was detected by the grasping force measurement experiment using an animal grasping force meter. The animal grasping force meter was provided by Jiangsu Sayons Biotechnology Co., Ltd., the product model is SANS, SA-417. The grip force determination experiment was repeated three times a day for 20 consecutive days.

[0049] 2. Experimental results

[0050] The results of the grip force measurement experiment are as follows: figure 2 shown. The results showed that there were statistical differences in the experimental results of the grasping force measurement between the young control group and the elderly control group, and the experimental results of the low-dose administration group, the high-dose administration group and the elder...

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Abstract

The invention relates to application of pulsatilla saponin B4 in preparation of a medicine or health food for preventing, relieving or treating sarcopenia, and belongs to the technical field of food and medicine. The pulsatilla saponin B4 or the pharmaceutically acceptable salt thereof has the effect of preventing, relieving or treating sarcopenia, and can be used for preparing medicines or health-care foods for preventing, relieving or treating sarcopenia. The pulsatilla saponin B4 belongs to traditional Chinese medicines, and when the pulsatilla saponin B4 or pharmaceutically acceptable salts thereof are used for preparing medicines or health-care foods for preventing, relieving or treating sarcopenia, the pulsatilla saponin B4 has the advantages of mild and lasting effect and small side effect.

Description

technical field [0001] The invention relates to the application of Pulsatilla saponin B4 in preparing medicine or health food for preventing, relieving or treating sarcopenia, and belongs to the technical field of food medicine. Background technique [0002] Sarcopenia, also known as sarcopenia syndrome, is a geriatric syndrome caused by the decline of skeletal muscle mass, strength and function with increasing age, also known as sarcopenia. The disease is characterized by extensive systemic skeletal muscle mass and function decline, combined with physical decline and mobility impairment, which in turn affects the quality of life, increases the risk of falls, hospitalization, and death, seriously endangering the health of the elderly. With the increasing aging of the world, sarcopenia has greatly affected the quality of life of the elderly, caused a serious economic burden to the society, and has become an increasingly serious social problem. At present, there is no effecti...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P21/00A61K36/71A23L33/125A61K125/00
CPCA61K31/704A61P21/00A61K36/71A23L33/125A23V2002/00A23V2200/316
Inventor 王继刚沈胜楠杨世林高红伟郭秋岩吕海宁唐欢徐承超
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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