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FGFR2c extracellular domain analogue and new application of coding gene thereof

A technology for encoding genes and extracellular segments, applied in FGFR2c extracellular segment analogs and their encoding genes and applications, can solve problems such as untargeted effective drugs and increased incidence of endometriosis

Pending Publication Date: 2022-08-02
江苏宜仙生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Individual susceptibility to endometriosis involves multiple factors, including hormonal abnormalities, immune response abnormalities, environmental factors, individual anatomy, and genetic or epigenetic predisposition, etc. Existing studies have also shown that uterine The cause of endometriosis is significantly related to genetic and environmental factors, and the incidence of endometriosis is still rising globally. In short, it is a complex multifactorial disease, and there is no targeted diagnosis so far. effective drug

Method used

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  • FGFR2c extracellular domain analogue and new application of coding gene thereof
  • FGFR2c extracellular domain analogue and new application of coding gene thereof
  • FGFR2c extracellular domain analogue and new application of coding gene thereof

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Experimental program
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Embodiment 1

[0044] Clean-grade female adult (9-10 weeks old) non-pregnant SD rats, weighing 190-210g, were randomly divided into sham operation group, model group, and treatment group. Each group finally included 10 rats, and the rats were in the third group. The EM (endometriosis) rat model was established by endometrial autotransplantation during estrus.

[0045] Seven days before the operation, each SD rat was intramuscularly injected with estradiol benzoate (0.1 mg / kg / d) to unify the estrous cycle. Donor SD rats: let them euthanize, take their endometrial tissue, put them in a petri dish filled with normal saline, and remove excess adipose tissue. The uterine segment was cut along the longitudinal axis with ophthalmic scissors, cut into 3mm × 3mm segments, and placed in normal saline for use.

[0046] The recipient SD rats were weighed, and the rats were anesthetized by intraperitoneal injection of 30 mg / ml sodium pentobarbital at 60 mg / kg. Prepare the skin, fix the rat on the steri...

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Abstract

The invention discloses an application of an FGFR2c extracellular domain analogue in preparation of a medicine for preventing and treating endometriosis, and the FGFR2c extracellular domain analogue has a good effect of reducing the size of a mouse endometriosis focus and the fibrosis area, and is superior to that of a gestotrione group. A new means is provided for clinically preparing medicines for treating endometriosis and all diseases related to fibrosis.

Description

technical field [0001] The present invention belongs to the field of biotechnology, and more particularly, the present invention relates to FGFR2c extracellular segment analogs and their encoding genes and applications. Background technique [0002] The extracellular domain of human FGFRs includes three immunoglobulin domains, namely D1, D2, and D3 immunoglobulin-like domains. The D2 and D3 regions are the specific binding regions of FGFs ligands. Twenty-three human FGFs and five FGF receptors (Fgfrs) encoded by different genes have been identified. Different FGF family members play different biological roles, mainly in regulating cell proliferation, cell survival, cell differentiation and cell migration. [0003] In a previous study by the inventor of the present application, Chinese patent application 2020112332925, provided FGFR2c extracellular segment analogs and their encoding genes, which can be applied to inhibit pulmonary fibrosis. [0004] Endometriosis (EMs), th...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P11/00A61P15/00
CPCA61K38/179A61P15/00A61P11/00
Inventor 汪炬
Owner 江苏宜仙生物医药有限公司
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