Application of dental pulp stem cells in preparation of medicine for treating multiple sclerosis

A technology of multiple sclerosis and dental pulp stem cells, applied in the field of biomedicine, to achieve the effect of easy acquisition, inhibition of central inflammation, and reduction of spinal cord demyelination lesions

Pending Publication Date: 2022-08-09
BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its application in central nervous

Method used

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  • Application of dental pulp stem cells in preparation of medicine for treating multiple sclerosis
  • Application of dental pulp stem cells in preparation of medicine for treating multiple sclerosis
  • Application of dental pulp stem cells in preparation of medicine for treating multiple sclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0042] Example: Clinical symptoms and detection of demyelinating lesions and brain inflammation in EAE model mice

[0043] 1. Experimental animals: C57 / BL6 mice, 10 weeks old, female, were randomly divided into 4 groups of 10 mice, respectively:

[0044] Sham operation group Control group (Sham+Vehicle): Administer normal saline after sham operation:

[0045] Sham operation group and administration group (Sham+DPSC): dental pulp stem cell suspension was administered after sham operation;

[0046] Model group Control group (EAE+Vehicle): After modeling, normal saline was given:

[0047] Model group administration group (EAE+DPSC): dental pulp stem cell suspension was administered after modeling;

[0048] Preparation of dental pulp stem cell suspension: dental pulp stem cells were prepared at 1 × 10 6 The concentration per mL was dissolved in normal saline.

[0049] 2. Animal experiment method:

[0050] 2.1 Model establishment:

[0051] The mouse polypeptide antigen MOG35-...

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to application of dental pulp stem cells in preparation of a medicine for treating multiple sclerosis. The embodiment of the invention provides application of dental pulp stem cells in preparation of a medicine for treating multiple sclerosis. The dental pulp stem cells are simple and convenient to obtain, easy to amplify in vitro and high in multiplication capacity, and have clinical application advantages compared with other human body mesenchymal stem cells. Research shows that the dental pulp stem cells can obviously reduce EAE mouse spinal cord demyelination focus, reduce the injury area around the ventricle and reduce demyelination injury; in addition, immune cell infiltration in the brain can be obviously reduced, T cell infiltration is reduced, and central inflammation is inhibited.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of dental pulp stem cells in the preparation of medicines for multiple sclerosis. Background technique [0002] Multiple sclerosis (MS) is an autoimmune disease involving the central nervous system mediated by activated CD4+ T cells. Its main immune mechanism is that peripheral lymphocytes enter the CNS and cause irreversible inflammation of nerve fibers. Demyelination and axonal damage. Traditional medicines for the treatment of MS include Copaxone, interferon beta, etc., which have mild side effects but insignificant curative effects. New FDA-approved drugs such as Natalizumab and Fingolimod, which reduce neuroinflammation by inhibiting lymphocyte adhesion or migration, have been shown to be effective in MS, but may cause progressive Serious complications such as multifocal leukoencephalopathy and sudden cardiac death. [0003] Dental pulp ste...

Claims

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Application Information

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IPC IPC(8): A61K35/28A61P25/00A61P29/00A61P37/02
CPCA61K35/28A61P25/00A61P29/00A61P37/02
Inventor 王松灵周建施福东金薇娜王昊
Owner BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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