Donepezil hydrochloride dripping pills

A technology of donepezil hydrochloride and drop pills, which is applied in the directions of pill delivery, nervous system diseases, active ingredients of heterocyclic compounds, etc., can solve the problems of poor patient compliance, low bioavailability, and long treatment course of treatment, and achieves reduction of side effects and convenient swallowing. , the effect of accurate content

Inactive Publication Date: 2004-11-17
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug (1) is expensive and takes a long course of treatment; (2) depending on the patient's condition, it requires ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018] Prescription Dosage per 1000 capsules

[0019] Donepezil Hydrochloride 2.5g

[0020] Macrogol 4000 7.85g

[0021] Polyoxyethylene (40) stearate 7.85g

[0022] Liquid Paraffin Condenser

[0023] Operation process: Put polyethylene glycol and polyoxyethylene (40) stearate in a beaker, heat to 80°C to melt, add donepezil hydrochloride, stir and mix well, keep warm at 80°C±2°C, use 1mm drop the mixed solution into the cooled liquid paraffin, settle for 30 minutes, filter and wipe dry to obtain. Each pill weighs about 17mg and contains 2.5mg of donepezil hydrochloride

[0024] Prescription Dosage per 1000 capsules

[0025] Donepezil Hydrochloride 5g

[0026] Macrogol 4000 15.7g

[0027] Polyoxyethylene (40) stearate 15.7g

[0028] Liquid Paraffin Condenser

[0029] Operation process: Put polyethylene glycol and polyoxyethylene (40) stearate in a beaker, heat to 80°C to melt, add donepezil hydrochloride, stir and mix well, keep warm at 80°C±2°C, use 2mm drop the mix...

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PUM

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Abstract

Donepezil hydrochloride guttate pills contains Donepezil hydrochloride 6-16 wt%, water soluble supplementary material polyglycol-4000 0-94 wt% and polyethenoxy searate 0-94 wt%. The present invention is easy in separating dosage and has high biological utilization, stable quality and easy-to-control production condition.

Description

1. Technical field [0001] The invention relates to a donepezil hydrochloride dropping pill, which belongs to the technical field of western medicine preparations. 2. Technical background [0002] Donepezil hydrochloride is a drug for the treatment of mild to moderate dementia of the Alzheimer type and is also approved for the treatment of attention deficit disorder in children. Clinical drugs that can slow down the development of Alzheimer's disease include antioxidants, monoamine oxidase inhibitors, anti-inflammatory drugs and cholinease inhibitors, as well as bioengineering drugs that are still in the experimental stage, such as brain nerve repair agents. Among them, the efficacy of drugs that can correct or slow down the hypocholinergic function in the central nervous system has been recognized. In recent years, only tacrine hydrochloride and donepezil hydrochloride have been approved by the US FDA for the treatment of mild to moderate Alzheimer's d...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/445A61P25/28
Inventor 王志刚尼富苓
Owner SHANDONG NEWTIME PHARMA
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