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Gentiamarin powder infection for muscle injection and intravenous injection

A technology of gentiopicroside powder and injection, applied in the directions of anti-inflammatory agents, non-central analgesics, chemical instruments and methods, etc., can solve the problems of unstable intestinal tract and destruction, avoid overheating decomposition, easy to use, Appropriate effect of treatment

Inactive Publication Date: 2005-06-22
HARBIN GLORIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem of the instability of gentiopicroside when it is directly made into water injection and the problem that it is destroyed in the intestinal tract when it is taken orally, and to provide a process for preparing powder injection by purifying gentiopicroside from Gentiana and its method for preparing The application of liver-protecting and choleretic anti-inflammatory drugs, and the application of gentiopicroside derivatives as the preparation of liver-protecting and choleretic anti-inflammatory drugs

Method used

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  • Gentiamarin powder infection for muscle injection and intravenous injection
  • Gentiamarin powder infection for muscle injection and intravenous injection
  • Gentiamarin powder infection for muscle injection and intravenous injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Gentiopicroside powder injection for intramuscular and intravenous injection is prepared by the following process:

[0013] Take 1 kg of Gentiana herb and add 10 kg of water to decoct 3 times, 30 minutes each time, combine the decoction liquid, centrifuge to get the supernatant, gentiopicroside is easy to be decocted from the medicinal material. 10 kg of decoction on 10 kg of processed D101 macroporous resin column, the macroporous resin can absorb gentiopicroside, the macroporous resin column is eluted with 40 kg of water, the washing solution is discarded, and the macroporous resin is reused for 80 1kg of 30% ethanol was used for elution, and gentiopicroside could be resolved with dilute ethanol, and the ethanol in the eluate was recovered and dried under reduced pressure to obtain a residue. Dissolve the residue after recovering the eluent in 3 times the amount of 95% ethanol, filter, recover the ethanol from the filtrate and drain it, then dissolve it in 95% ethanol...

Embodiment 2

[0017] Add 1 kg of Gentiana herb and 20 kg of water to decoct 3 times, 1 hour each time, combine the decoction liquid, centrifuge to get the supernatant, and use 20 kg of processed D101 macroporous resin column for 10 kg of decoction, macroporous resin Use 60 kg of water to elute, discard the washing solution, and then use 100 kg of 10% ethanol to elute the macroporous resin column, recover the ethanol in the eluent, and dry it under reduced pressure to obtain a residue. The residue was dissolved in 5 times the amount of 95% ethanol, filtered, the filtrate recovered ethanol and drained, then dissolved in 95% ethanol, drained, and finally dissolved in concentrated ethanol, left to precipitate crystals, filtered to obtain gentian The pure product of picroside, the pure product of gentiopicroside and 20% mannitol for injection were dissolved in 5 times of water for injection, and the powder injection was prepared in the same way as in Example 1.

Embodiment 3

[0019] Take 1 kg of Gentiana herb and add 5 kg of water to decoct 3 times, 15 minutes each time, combine the decoction liquid, centrifuge to get the supernatant, 10 kg of water decoction with 50 kg of D101 macroporous resin column that has been processed, macroporous The resin was eluted with 20 kg of water, and the washing solution was discarded. The macroporous resin was then eluted with 30 kg of 70% ethanol. The ethanol in the eluent was recovered, and dried under reduced pressure to obtain a residue. After the eluent was recovered, The residue was dissolved in 2 times the amount of 95% ethanol, filtered, the filtrate recovered ethanol and drained, then dissolved in 95% ethanol, drained and finally dissolved in concentrated ethanol, left to precipitate crystals, filtered to obtain gentian The pure product of picroside, the pure product of gentiopicroside and 5% mannitol for injection were dissolved with 15 times of water for injection, and the powder injection was prepared i...

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Abstract

The invention relates to a process for purifying active ingredients of traditional Chinese medicine and preparing powder injection, in particular to the application of gentiopicroside purified from Gentiana quinquefolium to prepare powder injection and used as liver-protecting, choleretic and anti-inflammatory drug. It is prepared by the following process: Gentiana chinensis is decocted with water, and the decoction is adsorbed and eluted with a D101 macroporous resin column to obtain a residue. The residue is dissolved in 95% ethanol, filtered, placed, crystallized, filtered, and obtained. The pure product of bilipicroside, the pure product of gentiopicroside and mannitol for injection are dissolved in water for injection, filtered, subpackaged and freeze-dried to obtain the finished product. The purification process of the invention has low cost and no lipophilic components, which brings convenience to subsequent treatment. The purification method is simple and convenient, the gentiopicroside is separated from the raw material, and the yield is above 3%. The gentiopicroside of the present invention is made into freeze-dried powder injection for intravenous infusion, has good stability and is convenient to use.

Description

technical field [0001] The invention relates to a process for purifying active ingredients of traditional Chinese medicine and preparing powder injections, in particular to the application of the purified gentiopicroside from Gentiana quinquefolium to prepare powder injections and as liver-protecting, choleretic and anti-inflammatory drugs. Background technique [0002] Gentiopicroside is a split ring iridoid compound. It is mainly found in plants of the genus Gentiana of the family Gentianae. It has a relatively high content in Gentiana chinensis produced and cultivated in Shaanxi, up to 18%, generally 5%. It is the main active ingredient of gentian plants and an ideal raw material for pharmaceutical production. Gentiana chinensis is mixed with other traditional Chinese medicines and decocted in water. It is mainly used to treat arthritis, and it is very inconvenient to take. The total extract from Gentiana gentiani is called gentioglycosides, which is a mixture, the main...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P1/16A61P29/00C07H1/08C07H17/075
Inventor 孙文基尚平平杨旭民管建军
Owner HARBIN GLORIA PHARMA CO LTD
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