Aqueous liquid preparation

A technology of aqueous solution and eye drops, which is applied in the direction of non-central analgesics, anti-inflammatory agents, organic active ingredients, etc., and can solve problems such as instability to light

Inactive Publication Date: 2005-07-13
SENJU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is such a problem with pranoprofen, it is not stable to light in aqueous solution

Method used

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Examples

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preparation example Construction

[0028] The aqueous solution of the present invention can be produced according to a production method known per se, and can be produced in accordance with, for example, Japanese Pharmacopoeia Thirteenth Edition, General Rules for Preparation, Liquids and Solutions, Injections and Ophthalmic Solutions (The Japanese Pharmacopoeia thirteenth Edition, General Rules for Preparations, Liquids and Solutions, Injections and Ophthalmic Solutions.) described in the preparation method.

[0029] When the aqueous solution of the present invention is used as eye drops, it can be applied to trachoma, pink eye (acute conjunctivitis caused by bacteria or virus), stye, blepharitis, conjunctivitis, keratitis, corneal ulcer, dacryocystitis, etc. Wait. In the eye drops of the present invention, the ratio containing sulfamethoxazole is 4.0w / v%, and the ratio containing pranoprofen is 0.05w / v%, and its dose can be 3-6 drops per day. times (1-2 drops each time). The infusion frequency can be approp...

Embodiment 1

[0053] Aqueous solutions of eye drops are prepared in a conventional manner according to the following formulations.

[0054] Pranoprofen 0.05g

[0055] Sulfamethoxazole 4.0g

[0056] Sodium edetate 0.001g

[0057] Sodium hydroxide q.s.

[0058] Sterilized purified water ad 100ml

[0059] pH 8.3

Embodiment 2

[0061] Aqueous solutions of eye drops are prepared in a conventional manner according to the following formulations.

[0062] Pranoprofen 0.05g

[0063] Sulfamethoxazole 4.0g

[0064] Dipotassium Glycyrrhizinate 0.1g

[0065] Sodium edetate 0.001g

[0066] Sodium hydroxide q.s.

[0067] Sterilized purified water ad 100ml

[0068] pH 8.3

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PUM

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Abstract

The present invention provides an aqueous solution containing pranoprofen or a pharmacologically acceptable salt thereof, and a sulfa drug, and a method for making pranoprofen or a pharmacologically acceptable salt thereof stable to light in an aqueous solution, which includes adding a sulfa drug to the aqueous solution containing pranoprofen or a pharmacologically acceptable salt thereof.

Description

technical field [0001] The present invention relates to the aqueous solution containing pranoprofen or its pharmacologically acceptable salt, and sulfonamide drug. Furthermore, the present invention relates to a method for stabilizing pranoprofen or a pharmacologically acceptable salt thereof against light in an aqueous solution, the method comprising adding a sulfa drug. Background technique [0002] Pranoprofen (chemical name: α-methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid) is a non-steroidal anti-inflammatory Effective for inflammatory diseases of the anterior segment of the eye such as conjunctivitis, keratitis, blepharitis, etc. But pranoprofen has such a problem that it is unstable to light in aqueous solution. As a method for improving the photostability of pranoprofen in an aqueous solution, only one method is known, which method comprises the concomitant use of an antioxidant such as dibutylhydroxytoluene in an aqueous solution of pranoprofen in the prese...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/436A61K47/20A61P27/02A61P29/00C07D239/42C07D239/46C07D261/16C07D491/04C07D491/052
CPCA61K9/0048A61K31/436A61K47/20C07D239/42C07D239/47C07D261/16C07D491/04A61P27/02A61P29/00A61K2300/00A61K31/435
Inventor 中山久幸山﨑夫规子
Owner SENJU PHARMA CO LTD
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