Prepn process of artificial bone of coral hydroxyapatite with adjustable absorption speed

A coral hydroxyapatite, absorption speed technology, applied in medical science, prosthesis, etc., can solve the problems of no production, etc., achieve the effect of saving reagents, simple process, and low manufacturing cost

Inactive Publication Date: 2005-12-14
北京市意华健科贸有限责任公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Utilizing the respective characteristics of the above two materials in absorption speed, a new type of implant material that can adjust the absorption speed according to clinical needs is prepared, so that the absorption speed of the implant material in the human body can be equal to the growth speed of new bone. Ideal, but so far there are no examples of producing this material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] Reaction materials: pretreated coral, diammonium hydrogen phosphate, deionized water.

[0018] Preparation and conditions: 6 g of coral with an average pore size of 500 μm was uniformly immersed in 3 mol / L diammonium hydrogen phosphate solution. After taking it out, put it in the reactor, and use the steam generated by the reactor itself to heat the reaction. The reaction kettle was gradually heated to 240° C., kept for 2 hours and then gradually cooled. Take out the solid product for cleaning and sterilization.

[0019] The product is measured by a scanning electron microscope, and the thickness of the thin layer of hydroxyapatite on the surface of the channel is 4 μm. The content of hydroxyapatite is 13.0% according to X-ray powder diffraction spectrum and corresponding chemical method analysis.

example 2

[0021] Reaction materials: pretreated coral, ammonium dihydrogen phosphate, deionized water.

[0022] Preparation and conditions: 6 g of coral with an average pore size of 200 μm was uniformly immersed in a 5 mol / L ammonium dihydrogen phosphate solution. After taking it out, put it in the reactor, and use the steam generated by the reactor itself to heat the reaction. The reaction kettle was gradually heated to 240° C., and the reaction time was 24 hours. The solid product after the reaction is cleaned and sterilized.

[0023] The product is measured by a scanning electron microscope, and the thickness of the hydroxyapatite thin layer on the surface of the channel is 15 μm. According to X-ray powder diffraction spectrum and corresponding chemical method analysis, the content of hydroxyapatite is 28%.

example 3

[0025] Reaction materials: pretreated coral, ammonium phosphate, deionized water.

[0026] Preparation and conditions: immerse 10 g of coral with an average pore size of 300 μm in 3 mol / L ammonium phosphate solution evenly. After taking it out, put it in the reactor, and use the steam generated by the reactor itself to heat the reaction. The reaction temperature is 200°C, and the reaction time is 80 minutes. The solid product after the reaction is cleaned and sterilized.

[0027] The product is measured by a scanning electron microscope, and the thickness of the hydroxyapatite layer on the surface of the channel is 4 μm. According to X-ray powder diffraction spectrum and corresponding chemical analysis, the content of hydroxyapatite is 8.1%.

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Abstract

The invention relates to a preparation method of coral hydroxyapatite artificial bone with adjustable absorption speed. The hydroxyapatite artificial bone prepared from coral has excellent biocompatibility and bone affinity, and has a three-dimensional structure with pores connected to human bones, and its solubility in the human body is extremely small; the composition of coral is carbonic acid Calcium has relatively high solubility in the human body. If the orthopedic implant material is resorbed too quickly, new bone defects will be formed, and if the resorption is too slow, the growth rate of new bone will be retarded. The hydroxyapatite artificial bone prepared from coral possesses the respective advantages of the two, but so far there is no feasible preparation method. The method adopted in the present invention is that the selected corals are uniformly soaked in the soluble phosphate solution, and then put into a reaction kettle to heat and react with water vapor under temperature and pressure. The invention makes it possible for the coral hydroxyapatite artificial bone with adjustable absorption speed to be put into clinical application.

Description

Technical field: [0001] The invention relates to a preparation method of coral hydroxyapatite artificial bone, in particular to a preparation method of coral hydroxyapatite artificial bone with adjustable absorption speed. Background technique: [0002] At present, the hydroxyapatite artificial bone prepared from coral has been proved to be an excellent orthopedic implant material after more than 20 years of clinical and scientific research. It not only has excellent biocompatibility, bone affinity, Moreover, it has a three-dimensional space structure similar to that of human bone, which provides a suitable growth space for the growth of new bone. Hydroxyapatite has very little solubility in the human body and is very stable. Therefore, it is suitable to be used as an implant material that absorbs slowly or does not want to be absorbed, such as in the fields of ophthalmology and cosmetic plastic surgery. [0003] Corals with suitable pore size and sterilized treatment can ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12
Inventor 宋正孝董春生
Owner 北京市意华健科贸有限责任公司
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