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Medication for reducing blood fat and preparation method

A blood lipid-lowering and drug technology, applied in the field of blood-lipid lowering drugs and their preparation, can solve the problems of large dosage, poor bioavailability and the like

Inactive Publication Date: 2006-11-15
TIANJIN HONGRENTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, the existing dosage forms have the disadvantages of large dosage and poor bioavailability

Method used

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  • Medication for reducing blood fat and preparation method
  • Medication for reducing blood fat and preparation method
  • Medication for reducing blood fat and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0122] 1. Prescription: Puhuang 75g

[0123] 2. Preparation process: pack 75g of Puhuang medicinal material in a cloth bag, decoct twice, add 7 times the amount of water for the first time, decoct for 2 hours, and collect the filtrate; add 5 times the amount of water for the second time, decoct for 1 hour, The filtrate was collected and the two filtrates were combined. Then the filtrate is concentrated under reduced pressure to a relative density of 1.10, and the clear paste measured at 60°C is added with ethanol while stirring until the alcohol content reaches 80%. After fully stirring, it is left to stand for 24 hours, the supernatant is collected, the ethanol is recovered, and the ethanol is reduced. Concentrated under pressure to a relative density of 1.15, the clear paste measured at 60°C. Add polyethylene glycol 6000 by 2 times the amount of clear paste, melt at 80°C, mix with the above clear paste, use liquid paraffin as a condensing agent, and drop pills in a dropping...

Embodiment 2

[0125] 1. Prescription: Puhuang 150g

[0126] 2. Preparation process: pack 150g of Puhuang medicinal material in a cloth bag, decoct twice, add 7 times the amount of water for the first time, decoct for 2 hours, and collect the filtrate; add 5 times the amount of water for the second time, decoct for 1 hour, The filtrate was collected and the two filtrates were combined. Then the filtrate is concentrated under reduced pressure to a relative density of 1.10, and the clear paste measured at 60 ° C is added with ethanol while stirring until the alcohol content reaches 80%. After fully stirring, let stand for 24 hours, collect the supernatant, reclaim the ethanol, reduce Concentrated under pressure to a relative density of 1.15, the clear paste measured at 60°C. Add polyethylene glycol 6000 by 1.7 times of the amount of clear paste, melt at 80°C, mix with the above clear paste, use liquid paraffin as a condensing agent, and drop pills in a dropping pill machine (material temperat...

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Abstract

The present invention relates to the technical field of blood lipid-lowering drugs, specifically a drug for lowering blood fat made from Puhuang extract and a preparation method thereof, and a drop pill made from Puhuang as a raw material: Puhuang extract Add polyethylene glycol 6000, use liquid paraffin as a condensing agent, and coat with hypromellose, polysorbate-80, stevia, water, and absolute ethanol. The Puhuang Dropping Pill has a high bioavailability, and has the advantages of fast onset of action, easy disintegration, and easy absorption.

Description

technical field [0001] The invention relates to the technical field of blood lipid-lowering drugs, in particular to a blood-lipid-lowering drug made from extracts of Chinese medicinal materials and a preparation method thereof. Background technique [0002] The medicinal ingredients of Puhuang have been reported in the literature. According to the properties of the main fat-soluble components and flavonoids, the methods for extracting lipid-lowering drugs from Puhuang are currently as follows: [0003] 1. Patent application number 85104933, the title of the invention is "Method for Extracting Lipid-lowering Drugs from Puhuang". In the method, the medicinal materials are extracted with alcohol (ethanol containing water), concentrated, refrigerated and stratified, the lard-like fat-soluble part is taken, the acidity and alkalinity are adjusted, and then filtered, and the solvent is recovered to obtain the lipid-lowering active ingredient. But this method can only extract the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/88A61K9/20A61P3/06
Inventor 李永仓马洪波杨静赵喆
Owner TIANJIN HONGRENTANG PHARM CO LTD
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