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New application of berbamine as intracorporeal antitumor drug

A berberine and treatment technology, applied in the field of berberine's anti-tumor effect in vivo, can solve the problems that it is difficult to achieve effective tumor inhibition, and there is no clear conclusion on the anti-tumor effect of berberine in vivo

Inactive Publication Date: 2007-05-02
SUN YAT SEN UNIV CANCER CENT
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Problems solved by technology

Among these 4 articles, only 1 article actually involved the tumor-inhibitory effect in mice, and the experiment was only carried out in 1 tumor strain and 1 experiment. It was concluded that oral administration of berberine is difficult to achieve effective tumor-inhibiting effects
None of the other 3 articles are in vivo anti-tumor experiments in the actual sense, so up to now, there is no clear conclusion on the anti-tumor effect of berberine in vivo

Method used

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  • New application of berbamine as intracorporeal antitumor drug
  • New application of berbamine as intracorporeal antitumor drug
  • New application of berbamine as intracorporeal antitumor drug

Examples

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Embodiment Construction

[0012] The following experiments investigated the effect of berberine on mouse S 180 Tumor inhibitory effect of sarcoma, human nasopharyngeal carcinoma xenografts in nude mice and human colon carcinoma xenografts in nude mice. The drug is berberine hydrochloride tablets.

[0013] 1. Ber to Kunming mouse S 180 Tumor suppression experiment for sarcoma

[0014] Extract mice intraperitoneally inoculated with S 180 Sarcoma ascites cell suspension, diluted with normal saline to 1×10 6 The cell suspension was injected into the right underarm, 0.2mL per mouse. Carry out random grouping after 24h, establish negative control group (distilled water), positive control group (CTX, 5mg / kg), Ber low-dose group (10mg / kg), Ber medium-dose group (30mg / kg) and Ber high-dose group ( 50mg / kg). Ten mice in each group were administered orally once a day for 10 consecutive days. 24 hours after drug withdrawal, the mice were killed and the tumors were weighed. Use the formula (1) to calculate ...

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Abstract

The present invention is new application of berbamine as intracorporeal antitumor drug. Orally taken berbamine can reach effective tumor suppressing concentration for suppressing the growth of S180 sarcoma inside Kunming mouse's body and suppressing the growth of human nasopharyngeal carcinoma CNE2 cell and human colon cancer cell inside naked mouse's body.

Description

[technical field] [0001] The invention relates to a new use of berberine for its anti-tumor effect in vivo. [Background technique] [0002] Coptis chinensis, Coptis chinensis, Coptis deltoidea or Copttis teeta, a traditional Chinese medicine, is derived from the dried rhizome of Coptis chinensis, Coptis deltoidea or Coptis teeta. Berberine (also known as berberine, berberine, Berberine, referred to as Ber) is its main active ingredient, and it is also the main ingredient of dry rhizomes of plants such as Cortex Phellodendron and Three Needles. The molecular formula of berberine hydrochloride is: C 20 h 18 ClNO 4 2H 2 O. Molecular weight 407.85. Its pure product is yellow crystalline powder, odorless and extremely bitter. Soluble in hot water, slightly soluble in water or ethanol. The chemical structural formula of berberine (monomer) is: [0003] [0004] Berberine is a commonly used broad-spectrum antibacterial drug with high efficiency and low toxicity. It is m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61P35/00
Inventor 冼励坚蔡于琛
Owner SUN YAT SEN UNIV CANCER CENT
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