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Oral cavity plastering sheet of interferon and its preparation method

An oral patch and interferon technology, which is applied in the field of interferon preparations, can solve the problems of interferon preparations without oral ulcers and recurrent aphthous ulcers, and achieve the goal of improving drug compliance, reducing the number of administrations, and having no allergic reactions Effect

Active Publication Date: 2007-05-30
SHENZHEN NEPTUNUS INTERLONG BIO TECHN HLDG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Interferon preparations currently on the market include injections, suppositories, eye drops, gels, etc., but there are no interferon preparations for oral ulcers and recurrent aphthous ulcers caused by viral infections

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] I. Prescription

[0067] (1) Drug-containing layer prescription:

[0068] Interferon 5.0×10 7 IU

[0069] Lactose 49.0g

[0070] Sodium alginate 21.0g

[0071] Magnesium stearate 0.35g

[0072] (2) Protective layer prescription:

[0073] Polyvinyl alcohol 17-88 4.0g

[0074] Glycerin 8.0g

[0075] Yellow pigment 1.0g

[0076] Makes 1000 pieces

[0077] II. Preparation method

[0078] (1) Preparation of granules containing the main ingredient

[0079] Take the prepared freeze-dried product of interferon, mix it with the lactose of formula quantity by the method of increasing in equal amount, and pass through a 100-mesh sieve.

[0080] Add the prescribed amount of sodium alginate and magnesium stearate and mix well.

[0081] (2) Tablet

[0082] It can be obtained by compressing tablets with a diameter of 7 mm, each weighing about 70 mg, and containing 50,000 IU of interferon.

[0083] (3) Preparation of patch protection layer

[0084] Add 4.0g of polyvinyl ...

Embodiment 2

[0087] I. Prescription

[0088] (1) Drug-containing layer prescription:

[0089] Interferon 5.0×10 7 IU

[0090] Hydroxypropyl Cellulose 49.0g

[0091] Carbomer 21.0g

[0092] Magnesium stearate 0.35g

[0093] (2) Protective layer prescription:

[0094] Polyvinyl alcohol 17-99 4.0g

[0095] Glycerin 8.0g

[0096] Yellow pigment 1.0g

[0097] Makes 1000 pieces

[0098] II. Preparation method

[0099] (1) Preparation of granules containing the main ingredient

[0100] Take the prepared interferon freeze-dried product, mix it with the hydroxypropyl cellulose of formula quantity by the method of increasing in equal amount, and pass through a 100-mesh sieve.

[0101] Add the prescribed amount of Carbomer and Magnesium Stearate and mix well.

[0102] (2) Tablet

[0103] It can be obtained by compressing tablets with a diameter of 7 mm, each weighing about 70 mg, and containing 50,000 IU of interferon.

[0104] (3) Preparation of patch protection layer

[0105] Add 4.0...

Embodiment 3

[0107] I. Prescription

[0108] (1) Drug-containing layer prescription:

[0109] Interferon 5.0×10 7 IU

[0110] Carboxymethylcellulose 49.0g

[0111] Sodium alginate 21.0g

[0112] Magnesium stearate 0.35g

[0113] (2) Protective layer prescription:

[0114] Polyvinyl alcohol 17-88 4.0g

[0115] Glycerin 8.0g

[0116] Yellow pigment 1.0g

[0117] Makes 1000 pieces

[0118] II. Preparation method

[0119] (1) Preparation of granules containing the main ingredient

[0120] Take the prepared interferon freeze-dried product, mix it with the carboxymethyl cellulose of formula quantity by the method of increasing in equal amount, and pass through a 100-mesh sieve.

[0121] Add the prescribed amount of sodium alginate and magnesium stearate and mix well.

[0122] (2) Tablet

[0123] It can be obtained by compressing tablets with a diameter of 7 mm, each weighing about 70 mg, and containing 50,000 IU of interferon.

[0124] (3) Preparation of patch protection layer

[...

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Abstract

The invention relates to an oral cavity plastering sheet of interferon and its preparation method, wherein the oral plaster comprises two layers, the first layer is a drug-containing adhesive layer, another layer is a water-proof protective layer, the drug-containing adhesive layer contains interferon for decreasing medicinal dissolution to the opposite of the oral mucosa and the bidirectional adhesion of the tablet between gingival and oral mucosa, and reducing medicament imbibition into ulcer surface and feeling of discomfort in the oral cavity. The interferon oral cavity plaster can be applied for the clinic treatment of ulcerative stomatitis caused by viruses.

Description

technical field [0001] The invention relates to an interferon preparation, in particular to an interferon oral patch, which is used for treating oral diseases caused by viral infections. [0002] The invention also relates to a preparation method of the interferon oral patch. Background technique [0003] Interferon (IFN) was discovered in 1957. It is a class of secreted proteins with broad-spectrum antiviral, antitumor and immunomodulatory functions. Interferon (IFN) is divided into natural interferon and non-natural interferon. Non-natural interferon mainly refers to genetically engineered IFN, which has exactly the same biological activity as natural IFN. After the non-natural interferon enters the body, it can play the role of natural interferon. This process is regulated by other physiological factors, and this regulation is a normal physiological process of the human body, so it is relatively safe. [0004] According to the different sources of interferon-producing ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/21A61K9/70A61P1/02
Inventor 柴向东李久立何凌冰王妍潘韵
Owner SHENZHEN NEPTUNUS INTERLONG BIO TECHN HLDG
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